Early loss of Crebbp confers malignant stem cell properties on lymphoid progenitors

Early loss of Crebbp confers malignant stem cell properties on lymphoid progenitors

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Loss-of-function mutations of cyclic-AMP response element binding protein, binding protein (CREBBP) are prevalent in lymphoid malignancies. However, the tumour suppressor functions of CREBBP remain unclear. We demonstrate that loss of Crebbp in murine haematopoietic stem and progenitor cells (HSPCs)...

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Bibliographic Details
Main Authors: Horton, S, Giotopoulos, G, Yun, H, Vohra, S, Sheppard, O, Bashford-Rogers, R, Rashid, M, Clipson, A, Chan, W, Sasca, D, Yiangou, L, Osaki, H, Basheer, F, Gallipoli, P, Burrows, N, Erdem, A, Sybirna, A, Foerster, S, Zhao, W, Sustic, T, Petrunkina Harrison, A, Laurenti, E, Okosun, J, Hodson, D, Wright, P, Smith, K, Maxwell, P, Fitzgibbon, J, Du, M, Adams, D, Huntly, B
Format: Journal article
Language:English
Published: Springer Nature 2017

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