LAG-3: a very singular immune checkpoint

LAG-3: a very singular immune checkpoint

The mechanism of action of the lymphocyte checkpoint protein LAG-3 was always rather mysterious. It now seems to operate at least in part by recognizing and suppressing responses to stable complexes of peptide and major histocompatibility complex class II.

Dettagli Bibliografici
Autori principali:	Lui, Y, Davis, S
Natura:	Journal article
Lingua:	English
Pubblicazione:	Springer Nature 2018

Documenti analoghi

The promising immune checkpoint LAG-3 in cancer immunotherapy: from basic research to clinical application
di: Huo, Jin-Ling, et al.
Pubblicazione: (2022)

Immune checkpoints as therapeutic targets in autoimmunity
di: Paluch, C, et al.
Pubblicazione: (2018)

CHECKPOINT ATHERO: developing immune checkpoint-based therapeutics for atherosclerosis
di: Lutgens, E, et al.
Pubblicazione: (2023)

Singular vector autoregressions with deterministic terms: Strong consistency and lag order determination.
di: Nielsen, B
Pubblicazione: (2008)

Characterising peripheral responses to immune checkpoint inhibitors
di: Cooper, R
Pubblicazione: (2021)

Manipulating immune checkpoint signalling pathways with antibodies
di: Paluch, C
Pubblicazione: (2019)

Antigen presenting cells in cancer immunity and mediation of immune checkpoint blockade
di: Wang, Cassia, et al.
Pubblicazione: (2024)

Seronegative antibody‐mediated neurology after immune checkpoint inhibitors
di: Wilson, R, et al.
Pubblicazione: (2018)

Immune checkpoint modulation enhances HIV-1 antibody induction
di: Bradley, T, et al.
Pubblicazione: (2020)

Mathematical modelling of autoimmune myocarditis and the effects of immune checkpoint inhibitors
di: van der Vegt, SA
Pubblicazione: (2022)

New approaches to treating cancer using immune-checkpoint blockade
di: Fellermeyer, M
Pubblicazione: (2023)

Mathematical modelling of autoimmune myocarditis and the effects of immune checkpoint inhibitors
di: van der Vegt, S, et al.
Pubblicazione: (2022)

Apoptosis of tumor-infiltrating T lymphocytes: a new immune checkpoint mechanism
di: Zhu, J, et al.
Pubblicazione: (2018)

CIS is a potent checkpoint in NK cell–mediated tumor immunity
di: Delconte, RB, et al.
Pubblicazione: (2016)

Checkpoint
di: Ang, Tiffany Si Ying, et al.
Pubblicazione: (2008)

The Strength of Very Soft Clay Reinforced with Singular Bottom Ash Column
di: Muzamir, Hasan, et al.
Pubblicazione: (2011)

LSD1 ablation stimulates anti-tumor immunity and enables checkpoint blockade
di: Sheng, W, et al.
Pubblicazione: (2018)

Targeting adenosine-2 B receptor : a potential metabolic immune checkpoint
di: Tay, Hui Min
Pubblicazione: (2019)

3D microfluidic ex vivo culture of organotypic tumor spheroids to model immune checkpoint blockade
di: Portell, Andrew, et al.
Pubblicazione: (2018)

Radiation combined with macrophage depletion promotes adaptive immunity and potentiates checkpoint blockade
di: Jones, K, et al.
Pubblicazione: (2018)

Inhibition of tryptophan-dioxygenase activity increases the antitumor efficacy of immune checkpoint inhibitors
di: Schramme, F, et al.
Pubblicazione: (2019)

IL7 genetic variation and toxicity to immune checkpoint blockade in patients with melanoma
di: Taylor, CA, et al.
Pubblicazione: (2022)

Haploid genetic screening approach towards identifying novel regulators of immune checkpoints
di: Chandrasekar, V
Pubblicazione: (2021)

Intrinsic Resistance to Immune Checkpoint Blockade in a Mismatch Repair–Deficient Colorectal Cancer
di: Liu, David, et al.
Pubblicazione: (2020)

Genetic abrogation of immune checkpoints in antigen-specific cytotoxic T-lymphocyte as a potential alternative to blockade immunotherapy
di: Zhang, C, et al.
Pubblicazione: (2018)

Dissecting peripheral CD8+ T cell responses and immune interactions during immune checkpoint blockade for metastatic melanoma
di: Tong, O
Pubblicazione: (2023)

Gallic acid induces T-helper-1-like Treg cells and strengthens immune checkpoint blockade efficacy
di: Deng, B, et al.
Pubblicazione: (2022)

Polynomial distributed lags,
di: Hall, Robert Ernest
Pubblicazione: (2011)

The time-lag in cataloging/
di: 296411 Pope, S
Pubblicazione: (1973)

Recombinant single-cycle influenza virus with exchangeable pseudotypes allows repeated immunization to augment anti-tumour immunity with immune checkpoint inhibitors
di: Kandasamy, M, et al.
Pubblicazione: (2023)

The protein phosphatase 2A functions in the spindle position checkpoint by regulating the checkpoint kinase Kin4
di: Chan, Leon Y., et al.
Pubblicazione: (2013)

Multiparametric characterisation of peripheral immunity in recipients of checkpoint immunotherapy across a large patient cohort
di: Taylor, CA
Pubblicazione: (2022)

Association between a distinctive autoantibody-associated brainstem sensory syndrome and immune checkpoint inhibitors
di: Damato, V, et al.
Pubblicazione: (2022)

Obstacles for T-lymphocytes in the tumour microenvironment: therapeutic challenges, advances and opportunities beyond immune checkpoint
di: Verma, Navin Kumar, et al.
Pubblicazione: (2023)

Targeting PPAR-gamma counteracts tumour adaptation to immune-checkpoint blockade in hepatocellular carcinoma
di: Xiong, Zhewen, et al.
Pubblicazione: (2023)

Engineering protein-based modulators of allergic, temporal, and checkpoint blockade anti-cancer immunity
di: Rothschilds, Adrienne Marie.
Pubblicazione: (2019)

Clinical Potential of Kinase Inhibitors in Combination with Immune Checkpoint Inhibitors for the Treatment of Solid Tumors
di: Ahn, Ryuhjin, et al.
Pubblicazione: (2021)

Combination of immune checkpoint blockade with DNA cancer vaccine induces potent antitumor immunity against P815 mastocytoma
di: Lopes, A, et al.
Pubblicazione: (2018)

Structural modeling of LAG-3 protein and immunoglobulin domains
di: Lai, Marcel Chang Long
Pubblicazione: (2014)

A comprehensive analysis of key immune checkpoint receptors on tumor-infiltrating T cells from multiple types of cancer
di: Li, X, et al.
Pubblicazione: (2019)