Radiosynthesis of [18F]ArylSCF2H using aryl boronic acids, S-(chlorofluoromethyl)benzenesulfonothioate and [18F]fluoride
Herein, we report a mild and practical protocol for the copper-catalyzed chlorofluoromethylthiolation of (hetero)aryl boronic acids with the novel reagent PhSO2SCFClH. The resulting products are amenable to halogen exchange 18F-fluorination with cyclotron-produced [18F]fluoride affording [18F]ArSCF2...
| Main Authors: | , , , , , , , |
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| 格式: | Journal article |
| 語言: | English |
| 出版: |
Chinese Chemical Society
2020
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| _version_ | 1826270934384771072 |
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| author | Zhao, Q Isenegger, PG Wilson, TC Sap, JBI Guibbal, F Lu, L Gouverneur, V Shen, Q |
| author_facet | Zhao, Q Isenegger, PG Wilson, TC Sap, JBI Guibbal, F Lu, L Gouverneur, V Shen, Q |
| author_sort | Zhao, Q |
| collection | OXFORD |
| description | Herein, we report a mild and practical protocol for the copper-catalyzed chlorofluoromethylthiolation of (hetero)aryl boronic acids with the novel reagent PhSO2SCFClH. The resulting products are amenable to halogen exchange 18F-fluorination with cyclotron-produced [18F]fluoride affording [18F]ArSCF2H. This process highlights the combined value of reagent development and (hetero)aryl boron precursors for radiochemistry by adding the [18F]SCF2H group to the list of 18F-motifs within reach for positron emission tomography studies.
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| first_indexed | 2024-03-06T21:48:40Z |
| format | Journal article |
| id | oxford-uuid:4a7e3e8e-a93e-4bb6-abfa-01986c9517c7 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:48:40Z |
| publishDate | 2020 |
| publisher | Chinese Chemical Society |
| record_format | dspace |
| spelling | oxford-uuid:4a7e3e8e-a93e-4bb6-abfa-01986c9517c72022-03-26T15:37:54ZRadiosynthesis of [18F]ArylSCF2H using aryl boronic acids, S-(chlorofluoromethyl)benzenesulfonothioate and [18F]fluorideJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:4a7e3e8e-a93e-4bb6-abfa-01986c9517c7EnglishSymplectic ElementsChinese Chemical Society2020Zhao, QIsenegger, PGWilson, TCSap, JBIGuibbal, FLu, LGouverneur, VShen, QHerein, we report a mild and practical protocol for the copper-catalyzed chlorofluoromethylthiolation of (hetero)aryl boronic acids with the novel reagent PhSO2SCFClH. The resulting products are amenable to halogen exchange 18F-fluorination with cyclotron-produced [18F]fluoride affording [18F]ArSCF2H. This process highlights the combined value of reagent development and (hetero)aryl boron precursors for radiochemistry by adding the [18F]SCF2H group to the list of 18F-motifs within reach for positron emission tomography studies. |
| spellingShingle | Zhao, Q Isenegger, PG Wilson, TC Sap, JBI Guibbal, F Lu, L Gouverneur, V Shen, Q Radiosynthesis of [18F]ArylSCF2H using aryl boronic acids, S-(chlorofluoromethyl)benzenesulfonothioate and [18F]fluoride |
| title | Radiosynthesis of [18F]ArylSCF2H using aryl boronic acids, S-(chlorofluoromethyl)benzenesulfonothioate and [18F]fluoride |
| title_full | Radiosynthesis of [18F]ArylSCF2H using aryl boronic acids, S-(chlorofluoromethyl)benzenesulfonothioate and [18F]fluoride |
| title_fullStr | Radiosynthesis of [18F]ArylSCF2H using aryl boronic acids, S-(chlorofluoromethyl)benzenesulfonothioate and [18F]fluoride |
| title_full_unstemmed | Radiosynthesis of [18F]ArylSCF2H using aryl boronic acids, S-(chlorofluoromethyl)benzenesulfonothioate and [18F]fluoride |
| title_short | Radiosynthesis of [18F]ArylSCF2H using aryl boronic acids, S-(chlorofluoromethyl)benzenesulfonothioate and [18F]fluoride |
| title_sort | radiosynthesis of 18f arylscf2h using aryl boronic acids s chlorofluoromethyl benzenesulfonothioate and 18f fluoride |
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