Regulation of insulin-like growth factor (IGF)-I action by matrix metalloproteinase-3 involves selective disruption of IGF-I/IGF-binding protein-3 complexes.

IGF-I and IGF-II play important roles in growth and development via interactions with cell-surface receptors; however, in nature, IGFs are sequestered by at least six soluble, high-affinity IGF-binding proteins (IGFBPs), namely IGFBPs 1-6. Herein, we demonstrate that the stromal cell-derived extrace...

Szczegółowa specyfikacja

Opis bibliograficzny
Główni autorzy: Fowlkes, J, Serra, D, Bunn, R, Thrailkill, K, Enghild, J, Nagase, H
Format: Journal article
Język:English
Wydane: 2004