The linear ubiquitin assembly complex’s recruitment to signaling complexes: The role of HOIP’s zinc finger domains
The linear ubiquitin chain assembly complex (LUBAC) regulates NF-κB activation and prevents cell death by conjugating M1 polyubiquitin on inflammatory complexes through its catalytic subunit HOIP. Although the conjugation of M1 chains is well described, less is known about the mechanism of LUBAC’s r...
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| Format: | Thèse |
| Langue: | English |
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2021
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