The crystal structure of an LLL-configured depsipeptide substrate analogue bound to isopenicillin N synthase.

Isopenicillin N synthase (IPNS) is a non-heme iron(ii) oxidase, which catalyses the biosynthesis of isopenicillin N (IPN) from the tripeptide delta-l-alpha-aminoadipoyl-l-cysteinyl-d-valine (lld-ACV) in a remarkable oxidative bicyclisation reaction. The natural substrate for IPNS is the lld-configur...

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Hlavní autoři: Ge, W, Clifton, I, Stok, J, Adlington, R, Baldwin, J, Rutledge, P
Médium: Journal article
Jazyk:English
Vydáno: 2010