Genotype-specific MRD interpretation improves stratification in paediatric acute lymphoblastic leukaemia

Genotype-specific MRD interpretation improves stratification in paediatric acute lymphoblastic leukaemia

<strong>Purpose</strong> Minimal residual disease (MRD) and genetic abnormalities are important risk factors for outcome in acute lymphoblastic leukemia. Current risk algorithms dichotomize MRD data and do not assimilate genetics when assigning MRD risk, which reduces predictive accuracy...

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Xehetasun bibliografikoak
Egile Nagusiak:	O'Connor, D, Enshaei, A, Bartram, J, Hancock, J, Harrison, C, Hough, R, Samarasinghe, S, Schwab, C, Vora, A, Wade, R, Moppett, J, Moorman, A, Goulden, N
Formatua:	Journal article
Argitaratua:	American Society of Clinical Oncology 2017

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Late relapsing childhood lymphoblastic leukaemia.
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Late relapsing childhood acute lymphoblastic leukaemia.
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Intraocular relapse of childhood acute lymphoblastic leukaemia.
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Variables affecting kinetics of minimal residual disease clearance in children with lymphoblastic leukaemia; Results of the United Kingdom Medical Research Council (UK MRC) protocols ALL97, ALL97/99 and ALL2003.
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Thiopurine methyltransferase genotype-phenotype discordance and thiopurine active metabolite formation in childhood acute lymphoblastic leukaemia.
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Treatment of infants with lymphoblastic leukaemia: results of the UK Infant Protocols 1987-1999.
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Molecular mechanisms involved in chemoresistance in paediatric acute lymphoblastic leukaemia
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