A Bayesian phase 2 model based adaptive design to optimise antivenom dosing: Application to a dose-finding trial for a novel Russell's viper antivenom in Myanmar

A Bayesian phase 2 model based adaptive design to optimise antivenom dosing: Application to a dose-finding trial for a novel Russell's viper antivenom in Myanmar

For most antivenoms there is little information from clinical studies to infer the relationship between dose and efficacy or dose and toxicity. Antivenom dose-finding studies usually recruit too few patients (e.g. fewer than 20) relative to clinically significant event rates (e.g. 5%). Model based a...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron:	Watson, JA, Lamb, T, Holmes, J, Warrell, DA, Thwin, KT, Aung, ZL, Oo, MZ, Nwe, MT, Smithuis, F, Ashley, EA
Fformat:	Journal article
Iaith:	English
Cyhoeddwyd:	Public Library of Science 2020

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A Bayesian phase 2 model based adaptive design to optimise antivenom dosing: Application to a dose-finding trial for a novel Russell's viper antivenom in Myanmar.
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gan: Than, T, et al.
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gan: Warrell, D, et al.
Cyhoeddwyd: (1980)

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gan: Tan, K.Y., et al.
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gan: Phillips, R, et al.
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Cyhoeddwyd: (1988)

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gan: Habib, A, et al.
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Notes on the use of antivenom.
gan: Warrell, D
Cyhoeddwyd: (1983)

Polyspecific snake antivenom may help in antivenom crisis.
gan: Laing, G, et al.
Cyhoeddwyd: (2003)

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gan: Laing, G, et al.
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gan: Warrell, D, et al.
Cyhoeddwyd: (1974)

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Antivenoms and treatment of snake-bite
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Cyhoeddwyd: (1998)

Pharmacokinetics of three commercial antivenoms in patients envenomed by the Malayan pit viper, Calloselasma rhodostoma, in Thailand.
gan: Ho, M, et al.
Cyhoeddwyd: (1990)

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gan: Alfred, S, et al.
Cyhoeddwyd: (2019)

Proteomic Analysis, Immuno-Specificity and Neutralization Efficacy of Pakistani Viper Antivenom (PVAV), a Bivalent Anti-Viperid Antivenom Produced in Pakistan
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gan: Warrell, D
Cyhoeddwyd: (1991)

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Cyhoeddwyd: (2022-03-01)

Crisis in snake antivenom supply for Africa
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Cyhoeddwyd: (2000)

Crisis in snake antivenom supply for Africa.
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Cyhoeddwyd: (2000)

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Clinical studies of the effectiveness and safety of antivenoms
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Cyhoeddwyd: (2018)

Antithrombin III and antivenom reversal of coagulopathy in rats envenomated with Malayan pit viper venom.
gan: Pukrittayakamee, S, et al.
Cyhoeddwyd: (1994)