Dilated cardiomyopathy mutations in thin-filament regulatory proteins reduce contractility, suppress systolic Ca²⁺, and activate NFAT and Akt signaling

Dilated cardiomyopathy mutations in thin-filament regulatory proteins reduce contractility, suppress systolic Ca²⁺, and activate NFAT and Akt signaling

Dilated cardiomyopathy (DCM) is clinically characterized by dilated ventricular cavities and reduced ejection fraction, leading to heart failure and increased thromboembolic risk. Mutations in thin-filament regulatory proteins can cause DCM and have been shown in vitro to reduce contractility and my...

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Bibliographic Details
Main Authors:	Robinson, P, Sparrow, AJ, Patel, S, Malinowska, M, Reilly, SN, Zhang, YH, Casadei, B, Watkins, H, Redwood, C
Format:	Journal article
Language:	English
Published:	American Physiological Society 2020

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