Rapid degradation of oseltamivir phosphate in clinical samples by plasma esterases.
The anti-influenza drug oseltamivir is an ester prodrug activated by hepatic carboxylesterases. Plasma esterases also convert up to 31.8% of the parent compound to the active metabolite after 4 h ex vivo, with wide interindividual variation. This source of error is removed by adding the esterase inh...
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Bibliographic Details
| Main Authors: |
Lindegardh, N,
Davies, G,
Tran, T,
Farrar, J,
Singhasivanon, P,
Day, N,
White, N |
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| Format: | Journal article
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| Language: | English |
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| Published: |
2006
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