Rapid degradation of oseltamivir phosphate in clinical samples by plasma esterases.
The anti-influenza drug oseltamivir is an ester prodrug activated by hepatic carboxylesterases. Plasma esterases also convert up to 31.8% of the parent compound to the active metabolite after 4 h ex vivo, with wide interindividual variation. This source of error is removed by adding the esterase inh...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2006
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| _version_ | 1797066977554989056 |
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| author | Lindegardh, N Davies, G Tran, T Farrar, J Singhasivanon, P Day, N White, N |
| author_facet | Lindegardh, N Davies, G Tran, T Farrar, J Singhasivanon, P Day, N White, N |
| author_sort | Lindegardh, N |
| collection | OXFORD |
| description | The anti-influenza drug oseltamivir is an ester prodrug activated by hepatic carboxylesterases. Plasma esterases also convert up to 31.8% of the parent compound to the active metabolite after 4 h ex vivo, with wide interindividual variation. This source of error is removed by adding the esterase inhibitor dichlorvos to blood collection tubes. |
| first_indexed | 2024-03-06T21:49:41Z |
| format | Journal article |
| id | oxford-uuid:4ad0f9ea-adf1-4b88-b8b6-89143f5e682d |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:49:41Z |
| publishDate | 2006 |
| record_format | dspace |
| spelling | oxford-uuid:4ad0f9ea-adf1-4b88-b8b6-89143f5e682d2022-03-26T15:39:55ZRapid degradation of oseltamivir phosphate in clinical samples by plasma esterases.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:4ad0f9ea-adf1-4b88-b8b6-89143f5e682dEnglishSymplectic Elements at Oxford2006Lindegardh, NDavies, GTran, TFarrar, JSinghasivanon, PDay, NWhite, NThe anti-influenza drug oseltamivir is an ester prodrug activated by hepatic carboxylesterases. Plasma esterases also convert up to 31.8% of the parent compound to the active metabolite after 4 h ex vivo, with wide interindividual variation. This source of error is removed by adding the esterase inhibitor dichlorvos to blood collection tubes. |
| spellingShingle | Lindegardh, N Davies, G Tran, T Farrar, J Singhasivanon, P Day, N White, N Rapid degradation of oseltamivir phosphate in clinical samples by plasma esterases. |
| title | Rapid degradation of oseltamivir phosphate in clinical samples by plasma esterases. |
| title_full | Rapid degradation of oseltamivir phosphate in clinical samples by plasma esterases. |
| title_fullStr | Rapid degradation of oseltamivir phosphate in clinical samples by plasma esterases. |
| title_full_unstemmed | Rapid degradation of oseltamivir phosphate in clinical samples by plasma esterases. |
| title_short | Rapid degradation of oseltamivir phosphate in clinical samples by plasma esterases. |
| title_sort | rapid degradation of oseltamivir phosphate in clinical samples by plasma esterases |
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