Unravelling mononuclear phagocyte heterogeneity.
When Ralph Steinman and Zanvil Cohn first described dendritic cells (DCs) in 1973 it took many years to convince the immunology community that these cells were truly distinct from macrophages. Almost four decades later, the DC is regarded as the key initiator of adaptive immune responses; however, d...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
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2010
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| _version_ | 1826271001222053888 |
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| author | Geissmann, F Gordon, S Hume, D Mowat, A Randolph, G |
| author_facet | Geissmann, F Gordon, S Hume, D Mowat, A Randolph, G |
| author_sort | Geissmann, F |
| collection | OXFORD |
| description | When Ralph Steinman and Zanvil Cohn first described dendritic cells (DCs) in 1973 it took many years to convince the immunology community that these cells were truly distinct from macrophages. Almost four decades later, the DC is regarded as the key initiator of adaptive immune responses; however, distinguishing DCs from macrophages still leads to confusion and debate in the field. Here, Nature Reviews Immunology asks five experts to discuss the issue of heterogeneity in the mononuclear phagocyte system and to give their opinion on the importance of defining these cells for future research. |
| first_indexed | 2024-03-06T21:49:44Z |
| format | Journal article |
| id | oxford-uuid:4ad4cb52-dd7b-42f9-ad0b-d70cdd3565ec |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:49:44Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | oxford-uuid:4ad4cb52-dd7b-42f9-ad0b-d70cdd3565ec2022-03-26T15:39:55ZUnravelling mononuclear phagocyte heterogeneity.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:4ad4cb52-dd7b-42f9-ad0b-d70cdd3565ecEnglishSymplectic Elements at Oxford2010Geissmann, FGordon, SHume, DMowat, ARandolph, GWhen Ralph Steinman and Zanvil Cohn first described dendritic cells (DCs) in 1973 it took many years to convince the immunology community that these cells were truly distinct from macrophages. Almost four decades later, the DC is regarded as the key initiator of adaptive immune responses; however, distinguishing DCs from macrophages still leads to confusion and debate in the field. Here, Nature Reviews Immunology asks five experts to discuss the issue of heterogeneity in the mononuclear phagocyte system and to give their opinion on the importance of defining these cells for future research. |
| spellingShingle | Geissmann, F Gordon, S Hume, D Mowat, A Randolph, G Unravelling mononuclear phagocyte heterogeneity. |
| title | Unravelling mononuclear phagocyte heterogeneity. |
| title_full | Unravelling mononuclear phagocyte heterogeneity. |
| title_fullStr | Unravelling mononuclear phagocyte heterogeneity. |
| title_full_unstemmed | Unravelling mononuclear phagocyte heterogeneity. |
| title_short | Unravelling mononuclear phagocyte heterogeneity. |
| title_sort | unravelling mononuclear phagocyte heterogeneity |
| work_keys_str_mv | AT geissmannf unravellingmononuclearphagocyteheterogeneity AT gordons unravellingmononuclearphagocyteheterogeneity AT humed unravellingmononuclearphagocyteheterogeneity AT mowata unravellingmononuclearphagocyteheterogeneity AT randolphg unravellingmononuclearphagocyteheterogeneity |