'Feral' and 'wild'-type methicillin-resistant Staphylococcus aureus in the United Kingdom.
Circulation of methicillin-resistant Staphylococcus aureus (MRSA) outside hospitals could alter the impact of hospital-based control strategies. We investigated two groups of cases (each matched to controls with MRSA): 61 'community cases' not in acute hospital in the year before MRSA isol...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2010
|
| _version_ | 1797067020937723904 |
|---|---|
| author | Miller, R Walker, A Knox, K Wyllie, D Paul, J Haworth, E Mant, D Peto, T Crook, D |
| author_facet | Miller, R Walker, A Knox, K Wyllie, D Paul, J Haworth, E Mant, D Peto, T Crook, D |
| author_sort | Miller, R |
| collection | OXFORD |
| description | Circulation of methicillin-resistant Staphylococcus aureus (MRSA) outside hospitals could alter the impact of hospital-based control strategies. We investigated two groups of cases (each matched to controls with MRSA): 61 'community cases' not in acute hospital in the year before MRSA isolation; and 21 cases with ciprofloxacin-sensitive (CipS) MRSA. Multi-locus sequence typing, spa-typing and Panton-Valentine leukocidin gene testing were performed and demographics obtained. Additional questionnaires were completed by community case GPs. Community cases comprised 6% of Oxfordshire MRSA. Three community cases had received no regular healthcare or antibiotics: one was infected with CipS. Ninety-one percent of community cases had healthcare-associated sequence type (ST)22/36; CipS MRSA cases had heterogeneous STs but many had recent healthcare exposure. A substantial minority of UK MRSA transmission may occur outside hospitals. Hospital strains are becoming 'feral' or persisting in long-term carriers in the community with regular healthcare contacts; those with recent healthcare exposure may nevertheless acquire non-hospital epidemic MRSA strains in the community. |
| first_indexed | 2024-03-06T21:50:19Z |
| format | Journal article |
| id | oxford-uuid:4b071ce3-f698-4ebb-ae4f-9f60459c6c3f |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:50:19Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | oxford-uuid:4b071ce3-f698-4ebb-ae4f-9f60459c6c3f2022-03-26T15:41:09Z'Feral' and 'wild'-type methicillin-resistant Staphylococcus aureus in the United Kingdom.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:4b071ce3-f698-4ebb-ae4f-9f60459c6c3fEnglishSymplectic Elements at Oxford2010Miller, RWalker, AKnox, KWyllie, DPaul, JHaworth, EMant, DPeto, TCrook, DCirculation of methicillin-resistant Staphylococcus aureus (MRSA) outside hospitals could alter the impact of hospital-based control strategies. We investigated two groups of cases (each matched to controls with MRSA): 61 'community cases' not in acute hospital in the year before MRSA isolation; and 21 cases with ciprofloxacin-sensitive (CipS) MRSA. Multi-locus sequence typing, spa-typing and Panton-Valentine leukocidin gene testing were performed and demographics obtained. Additional questionnaires were completed by community case GPs. Community cases comprised 6% of Oxfordshire MRSA. Three community cases had received no regular healthcare or antibiotics: one was infected with CipS. Ninety-one percent of community cases had healthcare-associated sequence type (ST)22/36; CipS MRSA cases had heterogeneous STs but many had recent healthcare exposure. A substantial minority of UK MRSA transmission may occur outside hospitals. Hospital strains are becoming 'feral' or persisting in long-term carriers in the community with regular healthcare contacts; those with recent healthcare exposure may nevertheless acquire non-hospital epidemic MRSA strains in the community. |
| spellingShingle | Miller, R Walker, A Knox, K Wyllie, D Paul, J Haworth, E Mant, D Peto, T Crook, D 'Feral' and 'wild'-type methicillin-resistant Staphylococcus aureus in the United Kingdom. |
| title | 'Feral' and 'wild'-type methicillin-resistant Staphylococcus aureus in the United Kingdom. |
| title_full | 'Feral' and 'wild'-type methicillin-resistant Staphylococcus aureus in the United Kingdom. |
| title_fullStr | 'Feral' and 'wild'-type methicillin-resistant Staphylococcus aureus in the United Kingdom. |
| title_full_unstemmed | 'Feral' and 'wild'-type methicillin-resistant Staphylococcus aureus in the United Kingdom. |
| title_short | 'Feral' and 'wild'-type methicillin-resistant Staphylococcus aureus in the United Kingdom. |
| title_sort | feral and wild type methicillin resistant staphylococcus aureus in the united kingdom |
| work_keys_str_mv | AT millerr feralandwildtypemethicillinresistantstaphylococcusaureusintheunitedkingdom AT walkera feralandwildtypemethicillinresistantstaphylococcusaureusintheunitedkingdom AT knoxk feralandwildtypemethicillinresistantstaphylococcusaureusintheunitedkingdom AT wyllied feralandwildtypemethicillinresistantstaphylococcusaureusintheunitedkingdom AT paulj feralandwildtypemethicillinresistantstaphylococcusaureusintheunitedkingdom AT haworthe feralandwildtypemethicillinresistantstaphylococcusaureusintheunitedkingdom AT mantd feralandwildtypemethicillinresistantstaphylococcusaureusintheunitedkingdom AT petot feralandwildtypemethicillinresistantstaphylococcusaureusintheunitedkingdom AT crookd feralandwildtypemethicillinresistantstaphylococcusaureusintheunitedkingdom |