GluR-A-Deficient mice display normal acquisition of a hippocampus-dependent spatial reference memory task but are impaired during spatial reversal.
Acquisition and reversal of a spatial discrimination were assessed in an appetitive, elevated plus-maze task in 4 groups of mice: knockout mice lacking the AMPA receptor subunit GluR-A (GluR1), wild-type controls, mice with cytotoxic hippocampal lesions, and controls that had undergone sham surgery....
| 主要な著者: | , , , |
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| フォーマット: | Journal article |
| 言語: | English |
| 出版事項: |
2003
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| _version_ | 1826271045895585792 |
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| author | Bannerman, D Deacon, R Seeburg, P Rawlins, J |
| author_facet | Bannerman, D Deacon, R Seeburg, P Rawlins, J |
| author_sort | Bannerman, D |
| collection | OXFORD |
| description | Acquisition and reversal of a spatial discrimination were assessed in an appetitive, elevated plus-maze task in 4 groups of mice: knockout mice lacking the AMPA receptor subunit GluR-A (GluR1), wild-type controls, mice with cytotoxic hippocampal lesions, and controls that had undergone sham surgery. In agreement with previous studies using tasks such as the water maze, GluR-A(-/-) mice were unimpaired during acquisition of the spatial discrimination task, whereas performance in the hippocampalgroup remained at chance levels. In contrast to their performance during acquisition, the GluR-A(-/-) mice displayed a mild deficit during reversal of the spatial discrimination and were profoundly impaired during discrete trial, rewarded-alternation testing on the elevated T maze. The latter result suggests a short-term, flexible spatial working memory impairment in GluR-A(-/-) mice, which might also underlie their mild deficit during spatial reversal. |
| first_indexed | 2024-03-06T21:50:26Z |
| format | Journal article |
| id | oxford-uuid:4b112ea7-3d8c-426a-a744-bb1a2b7f8fa7 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:50:26Z |
| publishDate | 2003 |
| record_format | dspace |
| spelling | oxford-uuid:4b112ea7-3d8c-426a-a744-bb1a2b7f8fa72022-03-26T15:41:23ZGluR-A-Deficient mice display normal acquisition of a hippocampus-dependent spatial reference memory task but are impaired during spatial reversal.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:4b112ea7-3d8c-426a-a744-bb1a2b7f8fa7EnglishSymplectic Elements at Oxford2003Bannerman, DDeacon, RSeeburg, PRawlins, JAcquisition and reversal of a spatial discrimination were assessed in an appetitive, elevated plus-maze task in 4 groups of mice: knockout mice lacking the AMPA receptor subunit GluR-A (GluR1), wild-type controls, mice with cytotoxic hippocampal lesions, and controls that had undergone sham surgery. In agreement with previous studies using tasks such as the water maze, GluR-A(-/-) mice were unimpaired during acquisition of the spatial discrimination task, whereas performance in the hippocampalgroup remained at chance levels. In contrast to their performance during acquisition, the GluR-A(-/-) mice displayed a mild deficit during reversal of the spatial discrimination and were profoundly impaired during discrete trial, rewarded-alternation testing on the elevated T maze. The latter result suggests a short-term, flexible spatial working memory impairment in GluR-A(-/-) mice, which might also underlie their mild deficit during spatial reversal. |
| spellingShingle | Bannerman, D Deacon, R Seeburg, P Rawlins, J GluR-A-Deficient mice display normal acquisition of a hippocampus-dependent spatial reference memory task but are impaired during spatial reversal. |
| title | GluR-A-Deficient mice display normal acquisition of a hippocampus-dependent spatial reference memory task but are impaired during spatial reversal. |
| title_full | GluR-A-Deficient mice display normal acquisition of a hippocampus-dependent spatial reference memory task but are impaired during spatial reversal. |
| title_fullStr | GluR-A-Deficient mice display normal acquisition of a hippocampus-dependent spatial reference memory task but are impaired during spatial reversal. |
| title_full_unstemmed | GluR-A-Deficient mice display normal acquisition of a hippocampus-dependent spatial reference memory task but are impaired during spatial reversal. |
| title_short | GluR-A-Deficient mice display normal acquisition of a hippocampus-dependent spatial reference memory task but are impaired during spatial reversal. |
| title_sort | glur a deficient mice display normal acquisition of a hippocampus dependent spatial reference memory task but are impaired during spatial reversal |
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