Antimalarial drug resistance: a threat to malaria elimination
Increasing antimalarial drug resistance once again threatens effective antimalarial drug treatment, malaria control, and elimination. Artemisinin combination therapies (ACTs) are first-line treatment for uncomplicated falciparum malaria in all endemic countries, yet partial resistance to artemisinin...
| Huvudupphovsmän: | , |
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| Materialtyp: | Journal article |
| Språk: | English |
| Publicerad: |
Cold Spring Harbor Laboratory
2017
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| _version_ | 1826308349047603200 |
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| author | Menard, D Dondorp, A |
| author_facet | Menard, D Dondorp, A |
| author_sort | Menard, D |
| collection | OXFORD |
| description | Increasing antimalarial drug resistance once again threatens effective antimalarial drug treatment, malaria control, and elimination. Artemisinin combination therapies (ACTs) are first-line treatment for uncomplicated falciparum malaria in all endemic countries, yet partial resistance to artemisinins has emerged in the Greater Mekong Subregion. Concomitant emergence of partner drug resistance is now causing high ACT treatment failure rates in several areas. Genetic markers for artemisinin resistance and several of the partner drugs have been established, greatly facilitating surveillance. Single point mutations in the gene coding for the Kelch propeller domain of the K13 protein strongly correlate with artemisinin resistance. Novel regimens and strategies using existing antimalarial drugs will be needed until novel compounds can be deployed. Elimination of artemisinin resistance will imply elimination of all falciparum malaria from the same areas. In vivax malaria, chloroquine resistance is an increasing problem. |
| first_indexed | 2024-03-07T07:18:12Z |
| format | Journal article |
| id | oxford-uuid:4b1d721d-0825-49f2-ae4c-14dab109d6a5 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T07:18:12Z |
| publishDate | 2017 |
| publisher | Cold Spring Harbor Laboratory |
| record_format | dspace |
| spelling | oxford-uuid:4b1d721d-0825-49f2-ae4c-14dab109d6a52022-09-02T09:27:04ZAntimalarial drug resistance: a threat to malaria eliminationJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:4b1d721d-0825-49f2-ae4c-14dab109d6a5EnglishSymplectic ElementsCold Spring Harbor Laboratory2017Menard, DDondorp, AIncreasing antimalarial drug resistance once again threatens effective antimalarial drug treatment, malaria control, and elimination. Artemisinin combination therapies (ACTs) are first-line treatment for uncomplicated falciparum malaria in all endemic countries, yet partial resistance to artemisinins has emerged in the Greater Mekong Subregion. Concomitant emergence of partner drug resistance is now causing high ACT treatment failure rates in several areas. Genetic markers for artemisinin resistance and several of the partner drugs have been established, greatly facilitating surveillance. Single point mutations in the gene coding for the Kelch propeller domain of the K13 protein strongly correlate with artemisinin resistance. Novel regimens and strategies using existing antimalarial drugs will be needed until novel compounds can be deployed. Elimination of artemisinin resistance will imply elimination of all falciparum malaria from the same areas. In vivax malaria, chloroquine resistance is an increasing problem. |
| spellingShingle | Menard, D Dondorp, A Antimalarial drug resistance: a threat to malaria elimination |
| title | Antimalarial drug resistance: a threat to malaria elimination |
| title_full | Antimalarial drug resistance: a threat to malaria elimination |
| title_fullStr | Antimalarial drug resistance: a threat to malaria elimination |
| title_full_unstemmed | Antimalarial drug resistance: a threat to malaria elimination |
| title_short | Antimalarial drug resistance: a threat to malaria elimination |
| title_sort | antimalarial drug resistance a threat to malaria elimination |
| work_keys_str_mv | AT menardd antimalarialdrugresistanceathreattomalariaelimination AT dondorpa antimalarialdrugresistanceathreattomalariaelimination |