Recent progress in chemical approaches for the development of novel neuraminidase inhibitors
Influenza virus is the main cause of an infectious disease called influenza affecting the respiratory system including the throat, nose and lungs. Neuraminidase inhibitors are reagents used to block the enzyme called neuraminidase to prevent the influenza infection from spreading. Neuraminidase inhi...
| Main Authors: | , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Royal Society of Chemistry
2021
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| _version_ | 1797107471031992320 |
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| author | Mahal, A Duan, M Zinad, DS Mohapatra, RK Obaidullah, AJ Wei, X Pradhan, MK Das, D Kandi, V Zinad, HS Zhu, Q |
| author_facet | Mahal, A Duan, M Zinad, DS Mohapatra, RK Obaidullah, AJ Wei, X Pradhan, MK Das, D Kandi, V Zinad, HS Zhu, Q |
| author_sort | Mahal, A |
| collection | OXFORD |
| description | Influenza virus is the main cause of an infectious disease called influenza affecting the respiratory system including the throat, nose and lungs. Neuraminidase inhibitors are reagents used to block the enzyme called neuraminidase to prevent the influenza infection from spreading. Neuraminidase inhibitors are widely used in the treatment of influenza infection, but still there is a need to develop more potent agents for the more effective treatment of influenza. Complications of the influenza disease lead to death, and one of these complications is drug resistance; hence, there is an urgent need to develop more effective agents. This review focuses on the recent advances in chemical synthesis pathways used for the development of new neuraminidase agents along with the medicinal aspects of chemically modified molecules, including the structure–activity relationship, which provides further rational designs of more active small molecules. |
| first_indexed | 2024-03-07T07:15:05Z |
| format | Journal article |
| id | oxford-uuid:4b3451c1-ff31-4793-97c8-502ad79b3207 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T07:15:05Z |
| publishDate | 2021 |
| publisher | Royal Society of Chemistry |
| record_format | dspace |
| spelling | oxford-uuid:4b3451c1-ff31-4793-97c8-502ad79b32072022-08-12T12:32:04ZRecent progress in chemical approaches for the development of novel neuraminidase inhibitorsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:4b3451c1-ff31-4793-97c8-502ad79b3207EnglishSymplectic ElementsRoyal Society of Chemistry2021Mahal, ADuan, MZinad, DSMohapatra, RKObaidullah, AJWei, XPradhan, MKDas, DKandi, VZinad, HSZhu, QInfluenza virus is the main cause of an infectious disease called influenza affecting the respiratory system including the throat, nose and lungs. Neuraminidase inhibitors are reagents used to block the enzyme called neuraminidase to prevent the influenza infection from spreading. Neuraminidase inhibitors are widely used in the treatment of influenza infection, but still there is a need to develop more potent agents for the more effective treatment of influenza. Complications of the influenza disease lead to death, and one of these complications is drug resistance; hence, there is an urgent need to develop more effective agents. This review focuses on the recent advances in chemical synthesis pathways used for the development of new neuraminidase agents along with the medicinal aspects of chemically modified molecules, including the structure–activity relationship, which provides further rational designs of more active small molecules. |
| spellingShingle | Mahal, A Duan, M Zinad, DS Mohapatra, RK Obaidullah, AJ Wei, X Pradhan, MK Das, D Kandi, V Zinad, HS Zhu, Q Recent progress in chemical approaches for the development of novel neuraminidase inhibitors |
| title | Recent progress in chemical approaches for the development of novel neuraminidase inhibitors |
| title_full | Recent progress in chemical approaches for the development of novel neuraminidase inhibitors |
| title_fullStr | Recent progress in chemical approaches for the development of novel neuraminidase inhibitors |
| title_full_unstemmed | Recent progress in chemical approaches for the development of novel neuraminidase inhibitors |
| title_short | Recent progress in chemical approaches for the development of novel neuraminidase inhibitors |
| title_sort | recent progress in chemical approaches for the development of novel neuraminidase inhibitors |
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