Carbohydrate and domain architecture of an immature antibody glycoform exhibiting enhanced effector functions.
Antibodies contain a conserved glycosylation site that has emerged as a target for the modulation of antibody effector functions. The crystal structure of a biosynthetic intermediate of human IgG1, bearing immature oligomannose-type glycans and reported to display increased antibody-dependent cellul...
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Бібліографічні деталі
| Автори: |
Crispin, M,
Bowden, T,
Coles, C,
Harlos, K,
Aricescu, A,
Harvey, D,
Stuart, D,
Jones, E |
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| Формат: | Journal article
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| Мова: | English |
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| Опубліковано: |
2009
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