Expression of alloantigens LY-5 and LY-6 on cytotoxic effector cells.
With anti-Ly antisera and complement it has been possible to demonstrate that cytotoxic effector cells generated in vitro against allogeneic cells carry the alloantigen Ly-5 and Ly-6. The studies show that antisera directed against the Ly-6 antigens, together with complement, eliminate essentially a...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
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1977
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| _version_ | 1826271098030784512 |
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| author | Woody, J Feldmann, M Beverley, P McKenzie, I |
| author_facet | Woody, J Feldmann, M Beverley, P McKenzie, I |
| author_sort | Woody, J |
| collection | OXFORD |
| description | With anti-Ly antisera and complement it has been possible to demonstrate that cytotoxic effector cells generated in vitro against allogeneic cells carry the alloantigen Ly-5 and Ly-6. The studies show that antisera directed against the Ly-6 antigens, together with complement, eliminate essentially all of the killer cells, of the appropriate strain, while killing only 50 to 60% of Thy-1+ cells. Anti-Ly-5 antsera and complement lysed 55 to 65% of Thy-1+ cells and killed a significant portion, but not all, of the cytotoxic cells. The later finding was investigated in more detail since it suggested a degree of heterogeneity within the killer cell subpopulation. However, the data did not support that conclusion, at least for allogeneic killer cells. |
| first_indexed | 2024-03-06T21:51:16Z |
| format | Journal article |
| id | oxford-uuid:4b59e604-f90f-435c-8652-6289423aaca8 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:51:16Z |
| publishDate | 1977 |
| record_format | dspace |
| spelling | oxford-uuid:4b59e604-f90f-435c-8652-6289423aaca82022-03-26T15:43:04ZExpression of alloantigens LY-5 and LY-6 on cytotoxic effector cells.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:4b59e604-f90f-435c-8652-6289423aaca8EnglishSymplectic Elements at Oxford1977Woody, JFeldmann, MBeverley, PMcKenzie, IWith anti-Ly antisera and complement it has been possible to demonstrate that cytotoxic effector cells generated in vitro against allogeneic cells carry the alloantigen Ly-5 and Ly-6. The studies show that antisera directed against the Ly-6 antigens, together with complement, eliminate essentially all of the killer cells, of the appropriate strain, while killing only 50 to 60% of Thy-1+ cells. Anti-Ly-5 antsera and complement lysed 55 to 65% of Thy-1+ cells and killed a significant portion, but not all, of the cytotoxic cells. The later finding was investigated in more detail since it suggested a degree of heterogeneity within the killer cell subpopulation. However, the data did not support that conclusion, at least for allogeneic killer cells. |
| spellingShingle | Woody, J Feldmann, M Beverley, P McKenzie, I Expression of alloantigens LY-5 and LY-6 on cytotoxic effector cells. |
| title | Expression of alloantigens LY-5 and LY-6 on cytotoxic effector cells. |
| title_full | Expression of alloantigens LY-5 and LY-6 on cytotoxic effector cells. |
| title_fullStr | Expression of alloantigens LY-5 and LY-6 on cytotoxic effector cells. |
| title_full_unstemmed | Expression of alloantigens LY-5 and LY-6 on cytotoxic effector cells. |
| title_short | Expression of alloantigens LY-5 and LY-6 on cytotoxic effector cells. |
| title_sort | expression of alloantigens ly 5 and ly 6 on cytotoxic effector cells |
| work_keys_str_mv | AT woodyj expressionofalloantigensly5andly6oncytotoxiceffectorcells AT feldmannm expressionofalloantigensly5andly6oncytotoxiceffectorcells AT beverleyp expressionofalloantigensly5andly6oncytotoxiceffectorcells AT mckenziei expressionofalloantigensly5andly6oncytotoxiceffectorcells |