MT1-MMP-dependent cell migration: proteolytic and non-proteolytic mechanisms
Membrane-type 1 matrix metalloproteinase (MT1-MMP) is a type I transmembrane proteinase that belongs to the matrix metalloproteinase (MMP) family. It is a potent modifier of cellular microenvironment and promotes cell migration and invasion of a wide variety of cell types both in physiological and p...
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| Format: | Journal article |
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Portland Press
2019
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| _version_ | 1797067097217433600 |
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| author | Gifford, V Itoh, Y |
| author_facet | Gifford, V Itoh, Y |
| author_sort | Gifford, V |
| collection | OXFORD |
| description | Membrane-type 1 matrix metalloproteinase (MT1-MMP) is a type I transmembrane proteinase that belongs to the matrix metalloproteinase (MMP) family. It is a potent modifier of cellular microenvironment and promotes cell migration and invasion of a wide variety of cell types both in physiological and pathological conditions. It promotes cell migration by degrading extracellular matrix on the cell surface and creates a migration path, by modifying cell adhesion property by shedding cell adhesion molecules to increase cell motility, and by altering cellular metabolism. Thus, MT1-MMP is a multifunctional cell motility enhancer. In this review, we will discuss the current understanding of the proteolytic and non-proteolytic mechanism of MT1-MMP-dependent cell migration. |
| first_indexed | 2024-03-06T21:51:26Z |
| format | Journal article |
| id | oxford-uuid:4b682a88-42c5-466a-8f75-7eef27ef4d21 |
| institution | University of Oxford |
| last_indexed | 2024-03-06T21:51:26Z |
| publishDate | 2019 |
| publisher | Portland Press |
| record_format | dspace |
| spelling | oxford-uuid:4b682a88-42c5-466a-8f75-7eef27ef4d212022-03-26T15:43:21ZMT1-MMP-dependent cell migration: proteolytic and non-proteolytic mechanismsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:4b682a88-42c5-466a-8f75-7eef27ef4d21Symplectic Elements at OxfordPortland Press2019Gifford, VItoh, YMembrane-type 1 matrix metalloproteinase (MT1-MMP) is a type I transmembrane proteinase that belongs to the matrix metalloproteinase (MMP) family. It is a potent modifier of cellular microenvironment and promotes cell migration and invasion of a wide variety of cell types both in physiological and pathological conditions. It promotes cell migration by degrading extracellular matrix on the cell surface and creates a migration path, by modifying cell adhesion property by shedding cell adhesion molecules to increase cell motility, and by altering cellular metabolism. Thus, MT1-MMP is a multifunctional cell motility enhancer. In this review, we will discuss the current understanding of the proteolytic and non-proteolytic mechanism of MT1-MMP-dependent cell migration. |
| spellingShingle | Gifford, V Itoh, Y MT1-MMP-dependent cell migration: proteolytic and non-proteolytic mechanisms |
| title | MT1-MMP-dependent cell migration: proteolytic and non-proteolytic mechanisms |
| title_full | MT1-MMP-dependent cell migration: proteolytic and non-proteolytic mechanisms |
| title_fullStr | MT1-MMP-dependent cell migration: proteolytic and non-proteolytic mechanisms |
| title_full_unstemmed | MT1-MMP-dependent cell migration: proteolytic and non-proteolytic mechanisms |
| title_short | MT1-MMP-dependent cell migration: proteolytic and non-proteolytic mechanisms |
| title_sort | mt1 mmp dependent cell migration proteolytic and non proteolytic mechanisms |
| work_keys_str_mv | AT giffordv mt1mmpdependentcellmigrationproteolyticandnonproteolyticmechanisms AT itohy mt1mmpdependentcellmigrationproteolyticandnonproteolyticmechanisms |