Ephemeral protein binding to DNA shapes stable nuclear bodies and chromatin domains.

Fluorescence microscopy reveals that the contents of many (membrane-free) nuclear bodies exchange rapidly with the soluble pool while the underlying structure persists; such observations await a satisfactory biophysical explanation. To shed light on this, we perform large-scale Brownian dynamics sim...

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Hlavní autoři: Brackley, C, Liebchen, B, Michieletto, D, Mouvet, F, Cook, P, Marenduzzo, D
Médium: Journal article
Jazyk:English
Vydáno: Elsevier 2017