Genome-wide loss-of-function screen reveals an important role for the proteasome in HDAC inhibitor-induced apoptosis.

Genome-wide loss-of-function screen reveals an important role for the proteasome in HDAC inhibitor-induced apoptosis.

Aberrant acetylation has been strongly linked to tumorigenesis, and the modulation of acetylation through targeting histone deacetylases (HDACs) is gathering increasing pace as a viable therapeutic strategy. A genome-wide loss-of-function screen identified HR23B, which shuttles ubiquitinated cargo p...

Detaylı Bibliyografya
Asıl Yazarlar:	Fotheringham, S, Epping, M, Stimson, L, Khan, O, Wood, V, Pezzella, F, Bernards, R, La Thangue, N
Materyal Türü:	Journal article
Dil:	English
Baskı/Yayın Bilgisi:	2009

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