CIRCULATING CATECHOLAMINES, MELATONIN AND ENKEPHALIN IN MAN FOLLOWING ADMINISTRATION OF A MET-ENKEPHALIN ANALOG

The met-enkephalin analogue, D-Ala2-MePhe4-met-enkephalin-(C)-ol (DAMME), was given i.v. to 6 normal subjects. Elevations in plasma prolactin and growth hormone (GH) occurred in association with significant falls in plasma epinephrine and norepinephrine. Dopamine rose 90 min after saline, but this w...

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التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Grossman, A, Smith, R, Vanloon, G, Brown, G, Rees, L, Besser, G
التنسيق: Journal article
اللغة:English
منشور في: 1982
الوصف
الملخص:The met-enkephalin analogue, D-Ala2-MePhe4-met-enkephalin-(C)-ol (DAMME), was given i.v. to 6 normal subjects. Elevations in plasma prolactin and growth hormone (GH) occurred in association with significant falls in plasma epinephrine and norepinephrine. Dopamine rose 90 min after saline, but this was not seen after DAMME. Circulating melatonin and met-enkephalin levels failed to change. The data suggest that opiates may inhibit the release of plasma catecholamines, but do not alter endogenous levels of circulating met-enkephalin or elevate melatonin.