CIRCULATING CATECHOLAMINES, MELATONIN AND ENKEPHALIN IN MAN FOLLOWING ADMINISTRATION OF A MET-ENKEPHALIN ANALOG

The met-enkephalin analogue, D-Ala2-MePhe4-met-enkephalin-(C)-ol (DAMME), was given i.v. to 6 normal subjects. Elevations in plasma prolactin and growth hormone (GH) occurred in association with significant falls in plasma epinephrine and norepinephrine. Dopamine rose 90 min after saline, but this w...

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מידע ביבליוגרפי
Main Authors: Grossman, A, Smith, R, Vanloon, G, Brown, G, Rees, L, Besser, G
פורמט: Journal article
שפה:English
יצא לאור: 1982
תיאור
סיכום:The met-enkephalin analogue, D-Ala2-MePhe4-met-enkephalin-(C)-ol (DAMME), was given i.v. to 6 normal subjects. Elevations in plasma prolactin and growth hormone (GH) occurred in association with significant falls in plasma epinephrine and norepinephrine. Dopamine rose 90 min after saline, but this was not seen after DAMME. Circulating melatonin and met-enkephalin levels failed to change. The data suggest that opiates may inhibit the release of plasma catecholamines, but do not alter endogenous levels of circulating met-enkephalin or elevate melatonin.