Vanadate prevents glucocorticoid-induced apoptosis of osteoblasts in vitro and osteocytes in vivo.

Vanadate prevents glucocorticoid-induced apoptosis of osteoblasts in vitro and osteocytes in vivo.

Skeletal mass is maintained by a balance between formation and resorption, cell proliferation and apoptosis. In vitro, glucocorticoids (GCs) decrease extracellular signal-regulated kinases (ERK) activation by mitogens, thus inhibiting osteoblast proliferation. Both ERK activity and proliferation are...

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Bibliografiske detaljer
Main Authors:	Conradie, M, De Wet, H, Kotze, D, Burrin, J, Hough, F, Hulley, P
Format:	Journal article
Sprog:	English
Udgivet:	2007

Lignende værker

Vanadate protects osteoblasts in vitro and in vivo from glucocorticoid impairment of proliferation
af: Hulley, P, et al.
Udgivet: (2002)

The tyrosine phosphatase inhibitor vanadate protects osteoblasts from growth inhibition by glucocorticoids.
af: Hulley, P, et al.
Udgivet: (1999)

Lactoferrin protects osteoblasts and osteocytes from apoptosis
af: Locklin, R, et al.
Udgivet: (2009)

Rapid inhibitory effects of glucocorticoids on ERK activity and osteoblast proliferation occur via transcriptional upregulation of MKP-1
af: Horsch, K, et al.
Udgivet: (2004)

Rapid inhibitory effects of glucocorticoids on ERK activity and osteoblast proliferation occur via transcriptional upregulation of MKP-1
af: Horsch, K, et al.
Udgivet: (2004)

BIM is a novel regulator of glucocorticoid-induced apoptosis in osteoblasts
af: Espina, B, et al.
Udgivet: (2006)

Regulation of bim in glucocorticoid-mediated osteoblast apoptosis.
af: Espina, B, et al.
Udgivet: (2008)

Glucocorticoids inhibit osteoblast proliferation via transcriptional upregulation of MKP-1: A prime target for the development of novel osteo-anabolic agents
af: Hulley, P, et al.
Udgivet: (2003)

Glucocorticoid-induced osteoporosis in the rat is prevented by the tyrosine phosphatase inhibitor, sodium orthovanadate.
af: Hulley, P, et al.
Udgivet: (2002)

Overexpression of Bcl2 in osteoblasts inhibits osteoblast differentiation and induces osteocyte apoptosis.
af: Takeshi Moriishi, et al.
Udgivet: (2011-01-01)

Mitogen-activated protein kinase phosphatase 1/dual specificity phosphatase 1 mediates glucocorticoid inhibition of osteoblast proliferation.
af: Horsch, K, et al.
Udgivet: (2007)

Disruption of glucocorticoid signal in osteoblasts and osteocytes attenuates hindlimb unloading-induced bone loss in mice
af: Jiancheng Yang, et al.
Udgivet: (2016-10-01)

Skeletal muscle secreted factors prevent glucocorticoid-induced osteocyte apoptosis through activation of β-catenin
af: K Jähn, et al.
Udgivet: (2012-09-01)

MKP-1 knockout does not prevent glucocorticoid-induced bone disease in mice.
af: Conradie, M, et al.
Udgivet: (2011)

The identification of transcriptional targets associated with osteoblast apoptosis signaling in response to growth factor withdrawal
af: Liang, M, et al.
Udgivet: (2006)

Glucocorticoids induce rapid up-regulation of mitogen-activated protein kinase phosphatase-1 and dephosphorylation of extracellular signal-regulated kinase and impair proliferation in human and mouse osteoblast cell lines.
af: Engelbrecht, Y, et al.
Udgivet: (2003)

Pathogenesis of glucocorticoid osteoporosis: Role of tyrosine phosphatases
af: Hulley, P, et al.
Udgivet: (2001)

Glucocorticoids induce senescence in primary human tenocytes: in vitro and in vivo evidence
af: Poulsen, R, et al.
Udgivet: (2013)

Glucocorticoids induce senescence in primary human tenocytes: in vitro and in vivo evidence
af: Poulsen, R, et al.
Udgivet: (2013)

Partial prevention of glucocorticoid-induced osteocyte deterioration in young male mice with osteocrin gene therapy
af: Courtney M. Mazur, et al.
Udgivet: (2022-09-01)

Transcriptional activation of ENPP1 by osterix in osteoblasts and osteocytes
af: MM Gao, et al.
Udgivet: (2018-07-01)

Titanium particles damage osteocytes and inhibit osteoblast differentiation
af: Li Chen, et al.
Udgivet: (2020-07-01)

Connexin 43 Hemichannels Regulate Osteoblast to Osteocyte Differentiation
af: Rui Hua, et al.
Udgivet: (2022-05-01)

Investigation of mechanosensing and mechanoresponse mechanisms in osteoblasts and osteocytes: in vitro experiments targeting subcellular components
af: Nobuhiko NAKAO, et al.
Udgivet: (2022-08-01)

Ablation of Discoidin Domain Receptor 1 Provokes an Osteopenic Phenotype by Regulating Osteoblast/Osteocyte Autophagy and Apoptosis
af: Hsin-Chiao Chou, et al.
Udgivet: (2022-09-01)

Sulforaphane reverses glucocorticoid-induced apoptosis in osteoblastic cells through regulation of the Nrf2 pathway
af: Lin H, et al.
Udgivet: (2014-07-01)

Osteocyte-mediated mechanical response controls osteoblast differentiation and function
af: Heather VerValin Buck, et al.
Udgivet: (2024-03-01)

Bim as a potential target in osteoblast survival
af: Espina, B, et al.
Udgivet: (2005)

Alternative insulin signalling pathways in osteoblasts
af: Langeveldt, C, et al.
Udgivet: (2002)

PINK1-mediated mitophagy contributes to glucocorticoid-induced cathepsin K production in osteocytes
af: Jun Yuan, et al.
Udgivet: (2023-01-01)

Osteocyte network; a negative regulatory system for bone mass augmented by the induction of Rankl in osteoblasts and Sost in osteocytes at unloading.
af: Takeshi Moriishi, et al.
Udgivet: (2012-01-01)

Comparison of the effects of vitamin D metabolites on osteoblast and osteocyte bone cells
af: Zarei, A
Udgivet: (2015)

Roles of Sp7 in osteoblasts for the proliferation, differentiation, and osteocyte process formation
af: Qing Jiang, et al.
Udgivet: (2024-07-01)

Osteocytes/Osteoblasts Produce SAA3 to Regulate Hepatic Metabolism of Cholesterol
af: Shijiang Huang, et al.
Udgivet: (2024-06-01)

Retraction Note: Titanium particles damage osteocytes and inhibit osteoblast differentiation
af: Li Chen, et al.
Udgivet: (2020-11-01)

Osteoblast/osteocyte-derived interleukin-11 regulates osteogenesis and systemic adipogenesis
af: Bingzi Dong, et al.
Udgivet: (2022-11-01)

Author Correction: Alternating Differentiation and Dedifferentiation between Mature Osteoblasts and Osteocytes
af: Naruhiko Sawa, et al.
Udgivet: (2020-12-01)

Preosteocytes/osteocytes have the potential to dedifferentiate becoming a source of osteoblasts.
af: Elena Torreggiani, et al.
Udgivet: (2013-01-01)

Alternative insulin signalling pathways in osteoblast cell lines
af: Langeveldt, C, et al.
Udgivet: (2002)

An in vitro model for the development of mature bone containing an osteocyte network
af: Iordachescu, A, et al.
Udgivet: (2017)