Vanadate prevents glucocorticoid-induced apoptosis of osteoblasts in vitro and osteocytes in vivo.

Vanadate prevents glucocorticoid-induced apoptosis of osteoblasts in vitro and osteocytes in vivo.

Skeletal mass is maintained by a balance between formation and resorption, cell proliferation and apoptosis. In vitro, glucocorticoids (GCs) decrease extracellular signal-regulated kinases (ERK) activation by mitogens, thus inhibiting osteoblast proliferation. Both ERK activity and proliferation are...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser: Conradie, M, De Wet, H, Kotze, D, Burrin, J, Hough, F, Hulley, P
Format: Journal article
Sprache:English
Veröffentlicht: 2007

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