Vanadate prevents glucocorticoid-induced apoptosis of osteoblasts in vitro and osteocytes in vivo.
Skeletal mass is maintained by a balance between formation and resorption, cell proliferation and apoptosis. In vitro, glucocorticoids (GCs) decrease extracellular signal-regulated kinases (ERK) activation by mitogens, thus inhibiting osteoblast proliferation. Both ERK activity and proliferation are...
Egile Nagusiak: | Conradie, M, De Wet, H, Kotze, D, Burrin, J, Hough, F, Hulley, P |
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Formatua: | Journal article |
Hizkuntza: | English |
Argitaratua: |
2007
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Antzeko izenburuak
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Vanadate protects osteoblasts in vitro and in vivo from glucocorticoid impairment of proliferation
nork: Hulley, P, et al.
Argitaratua: (2002) -
The tyrosine phosphatase inhibitor vanadate protects osteoblasts from growth inhibition by glucocorticoids.
nork: Hulley, P, et al.
Argitaratua: (1999) -
Lactoferrin protects osteoblasts and osteocytes from apoptosis
nork: Locklin, R, et al.
Argitaratua: (2009) -
Rapid inhibitory effects of glucocorticoids on ERK activity and osteoblast proliferation occur via transcriptional upregulation of MKP-1
nork: Horsch, K, et al.
Argitaratua: (2004) -
Rapid inhibitory effects of glucocorticoids on ERK activity and osteoblast proliferation occur via transcriptional upregulation of MKP-1
nork: Horsch, K, et al.
Argitaratua: (2004)