Genomic epidemiology of artemisinin resistant malaria.
The current epidemic of artemisinin resistant Plasmodium falciparum in Southeast Asia is the result of a soft selective sweep involving at least 20 independent kelch13 mutations. In a large global survey, we find that kelch13 mutations which cause resistance in Southeast Asia are present at low freq...
Main Authors: | MalariaGEN Plasmodium falciparum Community Project, Miotto, O, Woodrow, C, Almagro-Garcia, J, Sinha, I, Ashley, E, Boni, M, Bull, P, Day, N, Dolecek, C, Dondorp, A, Fanello, C, Newton, P, Nosten, F, Price, R, White, N, Cornelius, V, Giacomantonio, R, Henrichs, C, Pearson, R, McVean, G, Rockett, K, Miles, A, Jeffery, B, Kwiatkowski, D |
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Format: | Journal article |
Language: | English |
Published: |
eLife Sciences
2016
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