H2-driven reduction of flavin by hydrogenase enables cleaner operation of nitroreductases for nitro-group to amine reductions

Hydrogenase-mediated reduction of flavin mononucleotide by H2 is exploited to enable cleaner application of nitroreductase enzymes for reduction of aromatic nitro functional groups. This turns the overall reaction into a biocatalytic hydrogenation. Use of flavin-containing nitroreductases in industr...

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Bibliographic Details
Main Authors: Ramirez, MA, Joseph Srinivasan, S, Cleary, SE, Todd, PMT, Reeve, HA, Vincent, KA
Format: Journal article
Language:English
Published: Frontiers Media 2022