H2-driven reduction of flavin by hydrogenase enables cleaner operation of nitroreductases for nitro-group to amine reductions
Hydrogenase-mediated reduction of flavin mononucleotide by H2 is exploited to enable cleaner application of nitroreductase enzymes for reduction of aromatic nitro functional groups. This turns the overall reaction into a biocatalytic hydrogenation. Use of flavin-containing nitroreductases in industr...
Main Authors: | Ramirez, MA, Joseph Srinivasan, S, Cleary, SE, Todd, PMT, Reeve, HA, Vincent, KA |
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Format: | Journal article |
Language: | English |
Published: |
Frontiers Media
2022
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