Longitudinal prostate-specific antigen reference ranges: Choosing the underlying model of age-related changes
Serial measurements of prostate-specific antigen (PSA) are used as a biomarker for men diagnosed with prostate cancer following an active monitoring programme. Distinguishing pathological changes from natural age-related changes is not straightforward. Here, we compare four approaches to modelling a...
| Egile Nagusiak: | , , , , , , , |
|---|---|
| Formatua: | Journal article |
| Hizkuntza: | English |
| Argitaratua: |
SAGE Publications
2013
|
| _version_ | 1826271172417814528 |
|---|---|
| author | Simpkin, A Metcalfe, C Martin, R Lane, J Donovan, J Hamdy, F Neal, D Tilling, K |
| author_facet | Simpkin, A Metcalfe, C Martin, R Lane, J Donovan, J Hamdy, F Neal, D Tilling, K |
| author_sort | Simpkin, A |
| collection | OXFORD |
| description | Serial measurements of prostate-specific antigen (PSA) are used as a biomarker for men diagnosed with prostate cancer following an active monitoring programme. Distinguishing pathological changes from natural age-related changes is not straightforward. Here, we compare four approaches to modelling age-related change in PSA with the aim of developing reference ranges for repeated measures of PSA. A suitable model for PSA reference ranges must satisfy two criteria. First, it must offer an accurate description of the trend of PSA on average and in individuals. Second, it must be able to make accurate predictions about new PSA observations for an individual and about the entire PSA trajectory for a new individual. |
| first_indexed | 2024-03-06T21:52:28Z |
| format | Journal article |
| id | oxford-uuid:4bc63a70-66fa-44d2-8bcd-d5fc3e566bfe |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:52:28Z |
| publishDate | 2013 |
| publisher | SAGE Publications |
| record_format | dspace |
| spelling | oxford-uuid:4bc63a70-66fa-44d2-8bcd-d5fc3e566bfe2022-03-26T15:45:35ZLongitudinal prostate-specific antigen reference ranges: Choosing the underlying model of age-related changesJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:4bc63a70-66fa-44d2-8bcd-d5fc3e566bfeEnglishSymplectic Elements at OxfordSAGE Publications2013Simpkin, AMetcalfe, CMartin, RLane, JDonovan, JHamdy, FNeal, DTilling, KSerial measurements of prostate-specific antigen (PSA) are used as a biomarker for men diagnosed with prostate cancer following an active monitoring programme. Distinguishing pathological changes from natural age-related changes is not straightforward. Here, we compare four approaches to modelling age-related change in PSA with the aim of developing reference ranges for repeated measures of PSA. A suitable model for PSA reference ranges must satisfy two criteria. First, it must offer an accurate description of the trend of PSA on average and in individuals. Second, it must be able to make accurate predictions about new PSA observations for an individual and about the entire PSA trajectory for a new individual. |
| spellingShingle | Simpkin, A Metcalfe, C Martin, R Lane, J Donovan, J Hamdy, F Neal, D Tilling, K Longitudinal prostate-specific antigen reference ranges: Choosing the underlying model of age-related changes |
| title | Longitudinal prostate-specific antigen reference ranges: Choosing the underlying model of age-related changes |
| title_full | Longitudinal prostate-specific antigen reference ranges: Choosing the underlying model of age-related changes |
| title_fullStr | Longitudinal prostate-specific antigen reference ranges: Choosing the underlying model of age-related changes |
| title_full_unstemmed | Longitudinal prostate-specific antigen reference ranges: Choosing the underlying model of age-related changes |
| title_short | Longitudinal prostate-specific antigen reference ranges: Choosing the underlying model of age-related changes |
| title_sort | longitudinal prostate specific antigen reference ranges choosing the underlying model of age related changes |
| work_keys_str_mv | AT simpkina longitudinalprostatespecificantigenreferencerangeschoosingtheunderlyingmodelofagerelatedchanges AT metcalfec longitudinalprostatespecificantigenreferencerangeschoosingtheunderlyingmodelofagerelatedchanges AT martinr longitudinalprostatespecificantigenreferencerangeschoosingtheunderlyingmodelofagerelatedchanges AT lanej longitudinalprostatespecificantigenreferencerangeschoosingtheunderlyingmodelofagerelatedchanges AT donovanj longitudinalprostatespecificantigenreferencerangeschoosingtheunderlyingmodelofagerelatedchanges AT hamdyf longitudinalprostatespecificantigenreferencerangeschoosingtheunderlyingmodelofagerelatedchanges AT neald longitudinalprostatespecificantigenreferencerangeschoosingtheunderlyingmodelofagerelatedchanges AT tillingk longitudinalprostatespecificantigenreferencerangeschoosingtheunderlyingmodelofagerelatedchanges |