Modelling aspects of solid cancer growth
The modelling of cancer provides an enormous mathematical challenge because of its inherent multiscale nature. For example, in vascular tumours, nutrient is transported by the vascular system, which operates on a tissue level. However, it affects processes occurring on a molecular level. Molecular a...
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| Format: | Journal article |
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2008
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| _version_ | 1797067170110242816 |
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| author | Maini, P |
| author_facet | Maini, P |
| author_sort | Maini, P |
| collection | OXFORD |
| description | The modelling of cancer provides an enormous mathematical challenge because of its inherent multiscale nature. For example, in vascular tumours, nutrient is transported by the vascular system, which operates on a tissue level. However, it affects processes occurring on a molecular level. Molecular and intra-cellular events in turn effect the vascular network and therefore the nutrient dynamics. Our modelling approach is to model, using partial differential equations, processes on the tissue level and couple these to the intercellular events (modelled by ordinary differential equations) via cells modelled as automaton units. Thusfar, within this framework we have modelled structural adaptation at the vessel level and the effects of growth factor production in response to hypoxia. We have also investigated the effects of acid production, mutation and phenotypic evolution driven by tissue environment. These results will be presented. |
| first_indexed | 2024-03-06T21:52:31Z |
| format | Journal article |
| id | oxford-uuid:4bcab885-815e-4136-bdf8-cba633d0b833 |
| institution | University of Oxford |
| last_indexed | 2024-03-06T21:52:31Z |
| publishDate | 2008 |
| record_format | dspace |
| spelling | oxford-uuid:4bcab885-815e-4136-bdf8-cba633d0b8332022-03-26T15:45:39ZModelling aspects of solid cancer growthJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:4bcab885-815e-4136-bdf8-cba633d0b833Mathematical Institute - ePrints2008Maini, PThe modelling of cancer provides an enormous mathematical challenge because of its inherent multiscale nature. For example, in vascular tumours, nutrient is transported by the vascular system, which operates on a tissue level. However, it affects processes occurring on a molecular level. Molecular and intra-cellular events in turn effect the vascular network and therefore the nutrient dynamics. Our modelling approach is to model, using partial differential equations, processes on the tissue level and couple these to the intercellular events (modelled by ordinary differential equations) via cells modelled as automaton units. Thusfar, within this framework we have modelled structural adaptation at the vessel level and the effects of growth factor production in response to hypoxia. We have also investigated the effects of acid production, mutation and phenotypic evolution driven by tissue environment. These results will be presented. |
| spellingShingle | Maini, P Modelling aspects of solid cancer growth |
| title | Modelling aspects of solid cancer growth |
| title_full | Modelling aspects of solid cancer growth |
| title_fullStr | Modelling aspects of solid cancer growth |
| title_full_unstemmed | Modelling aspects of solid cancer growth |
| title_short | Modelling aspects of solid cancer growth |
| title_sort | modelling aspects of solid cancer growth |
| work_keys_str_mv | AT mainip modellingaspectsofsolidcancergrowth |