The role of two pore channels (TPCs) in pancreatic beta cell stimulus-secretion coupling

The role of two pore channels (TPCs) in pancreatic beta cell stimulus-secretion coupling

<p>This thesis presents an investigation into the role of the recently identified two pore channels (TPCs) in beta-cell stimulus-secretion coupling. TPCs are the receptors for calcium mobilising messenger nicotinic acid adenine dinucleotide phosphate (NAADP) located in the membrane of acidic i...

Fuld beskrivelse

Bibliografiske detaljer
Hovedforfatter:	Heister, P
Andre forfattere:	Galione, A
Format:	Thesis
Sprog:	English
Udgivet:	2012
Fag:	Diabetes Pharmacology Biology (medical sciences) Physiology

Lignende værker

Characterization of mouse two-pore channels (TPCs) in NAADP-mediated Ca(2+) signalling
af: Chuang, KT
Udgivet: (2011)

THE ROLE OF ION CHANNELS IN STIMULUS-SECRETION COUPLING IN PANCREATIC BETA-CELLS
af: Ashcroft, F, et al.
Udgivet: (1990)

Study of the roles of two pore channels (TPCs) in metabolism
af: Zhang, YL
Udgivet: (2023)

Stimulus-secretion coupling in pancreatic beta cells.
af: Ashcroft, F, et al.
Udgivet: (1994)

Expression of two-pore channels in mammalian primary cells and tissues, and their role in adipose tissue formation and function
af: Tunn, R
Udgivet: (2012)

Characterisation of the human two-pore channels
af: Funnell, T, et al.
Udgivet: (2011)

Stimulus-secretion coupling in L cells and factors affecting secretion of glucagon-like peptide 1
af: Cyranka, M
Udgivet: (2023)

Analysis of mouse models of insulin secretion disorders
af: Kaizik, S
Udgivet: (2010)

Mechanism of action and functional role of the two-pore channels (TPCs) in key vertebrate physiological processes
af: Chan, L
Udgivet: (2015)

Electrogenic arginine transport mediates stimulus-secretion coupling in mouse pancreatic beta-cells.
af: Smith, P, et al.
Udgivet: (1997)

THE ROLE OF THE ATP-SENSITIVE K-CHANNEL IN STIMULUS-RESPONSE COUPLING IN THE PANCREATIC BETA-CELL
af: Ashcroft, S, et al.
Udgivet: (1989)

The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
af: Galione, A, et al.
Udgivet: (2009)

Electrophysiological characterization of the human two-pore channel 2
af: Lam, A
Udgivet: (2015)

PGE2 in fibrosis and cancer: Insights into fibroblast activation
af: Elwakeel, Eiman, et al.
Udgivet: (2023)

Roles for the long non-coding RNA Pax6os1/PAX6-AS1 in pancreatic beta cell function
af: Livia Lopez-Noriega, et al.
Udgivet: (2025-01-01)

Effects of activating KATP channel mutations on neuronal function
af: McTaggart, J, et al.
Udgivet: (2011)

Actions of NAADP and other agents in cardiac myocytes
af: Bayliss, R
Udgivet: (2014)

Ibrutinib-induced pulmonary angiotensin-converting enzyme activation promotes atrial fibrillation in rats
af: Sen Yan, et al.
Udgivet: (2024-02-01)

n-3 polyunsaturated fatty acids delay intervertebral disc degeneration by inhibiting nuclear receptor coactivator 4-mediated iron overload
af: Xiang Ao, et al.
Udgivet: (2024-02-01)

Canagliflozin combined with aerobic exercise protects against chronic heart failure in rats
af: Helin Sun, et al.
Udgivet: (2024-03-01)

An imbalanced GLP-1R/GIPR co-agonist peptide with a site-specific N-terminal PEGylation to maximize metabolic benefits
af: Xuan Xia, et al.
Udgivet: (2024-04-01)

Asymmetry of hippocampal function in mice: left-right differences in memory processing and vulnerability to amyloid beta
af: Shipton, O, et al.
Udgivet: (2014)

Timing- and pattern-dependent long-term depression during mouse barrel cortex development
af: Banerjee, A
Udgivet: (2010)

Dietary or pharmacological inhibition of insulin-like growth factor-1 protects from renal ischemia-reperfusion injury in mice
af: Arnaud Lyon, et al.
Udgivet: (2024-12-01)

Endolysosomal TPCs regulate social behavior by controlling oxytocin secretion
af: Martucci, LL, et al.
Udgivet: (2023)

The endoplasmic reticulum plays a key role in α-cell intracellular Ca2+ dynamics and glucose-regulated glucagon secretion in mouse islets
af: Samuel Acreman, et al.
Udgivet: (2024-05-01)

Preclinical validation of human recombinant glutamate-oxaloacetate transaminase for the treatment of acute ischemic stroke
af: María Pérez-Mato, et al.
Udgivet: (2024-11-01)

GSK2334470 attenuates high salt-exacerbated rheumatoid arthritis progression by restoring Th17/Treg homeostasis
af: Qian Mo, et al.
Udgivet: (2024-06-01)

Differentiate the roles of CA channel subtypes in insulin secretion
af: Chen, Peng.
Udgivet: (2010)

Investigating the role of Viperin in beta-cell function and inflammation
af: Tebeka, N
Udgivet: (2020)

Mechanisms of storage and release of vasoactive molecules in endothelial cells – Endothelin-1
af: Banecki, KMRM
Udgivet: (2024)

The influence of selected sulphur containing compounds on retinal cell death: neuroprotective effects of hydrogen sulphide in a glaucoma model
af: Abdul Majid, A
Udgivet: (2011)

Third-generation taxanes SB-T-121605 and SB-T-121606 are effective in pancreatic ductal adenocarcinoma
af: Tomas Sychra, et al.
Udgivet: (2024-02-01)

Pyroglutamic acidosis in the setting of Staphylococcus aureus bacteremia treated with flucloxacillin—An uncommon cause of high anion gap metabolic acidosis
af: Aaron Yee Shuen See, et al.
Udgivet: (2024-08-01)

Study of catecholaminergic cells in murine heart
af: Sun, T
Udgivet: (2021)

Ca2+i and the pancreatic α cell – intrinsic regulation and dysfunction in type 2 diabetes
af: Kellard, J
Udgivet: (2019)

A dopamine D1-like receptor-specific agonist improves the survival of septic mice
af: Koichi Tanaka, et al.
Udgivet: (2024-04-01)

The mechanisms and therapeutic potential of clopidogrel in mitigating diabetic cardiomyopathy in db/db mice
af: Bing Li, et al.
Udgivet: (2024-03-01)

Arginine methylation in the E2F1 pathway
af: Zheng, S
Udgivet: (2013)

Anode-coupled readout for light collection in Liquid Argon TPCs
af: Moss, Z., et al.
Udgivet: (2017)