Circulating soluble fms-like tyrosine kinase-1 is placentally derived in normal pregnancy: first in vivo evidence
Circulating sFlt-1 increases significantly in pregnancy compared to the non-pregnant state and even more so in the event of preeclampsia. We set out to determine if circulating sFlt-1 is placentally derived in normal pregnancy. Paired uterine and peripheral vein samples were collected at time of cae...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Elsevier
2019
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| _version_ | 1797067201792966656 |
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| author | Cerdeira, AS Kandzija, N Pargmae, P Cooke, W James, T Redman, C Vatish, M |
| author_facet | Cerdeira, AS Kandzija, N Pargmae, P Cooke, W James, T Redman, C Vatish, M |
| author_sort | Cerdeira, AS |
| collection | OXFORD |
| description | Circulating sFlt-1 increases significantly in pregnancy compared to the non-pregnant state and even more so in the event of preeclampsia. We set out to determine if circulating sFlt-1 is placentally derived in normal pregnancy. Paired uterine and peripheral vein samples were collected at time of caesarean section. A follow up peripheral sample was collected in the postpartum period. There was a significant sFlt-1 gradient between uterine and peripheral veins. sFlt-1 levels dropped significantly when the placenta has been removed, i.e. postnatally. This is in keeping with the placenta being the main site of sFlt-1 production in normal pregnancies. |
| first_indexed | 2024-03-06T21:52:59Z |
| format | Journal article |
| id | oxford-uuid:4bf33c13-19c0-47f0-8b76-c28d9c8327c4 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:52:59Z |
| publishDate | 2019 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:4bf33c13-19c0-47f0-8b76-c28d9c8327c42022-03-26T15:46:33ZCirculating soluble fms-like tyrosine kinase-1 is placentally derived in normal pregnancy: first in vivo evidenceJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:4bf33c13-19c0-47f0-8b76-c28d9c8327c4EnglishSymplectic Elements at OxfordElsevier2019Cerdeira, ASKandzija, NPargmae, PCooke, WJames, TRedman, CVatish, MCirculating sFlt-1 increases significantly in pregnancy compared to the non-pregnant state and even more so in the event of preeclampsia. We set out to determine if circulating sFlt-1 is placentally derived in normal pregnancy. Paired uterine and peripheral vein samples were collected at time of caesarean section. A follow up peripheral sample was collected in the postpartum period. There was a significant sFlt-1 gradient between uterine and peripheral veins. sFlt-1 levels dropped significantly when the placenta has been removed, i.e. postnatally. This is in keeping with the placenta being the main site of sFlt-1 production in normal pregnancies. |
| spellingShingle | Cerdeira, AS Kandzija, N Pargmae, P Cooke, W James, T Redman, C Vatish, M Circulating soluble fms-like tyrosine kinase-1 is placentally derived in normal pregnancy: first in vivo evidence |
| title | Circulating soluble fms-like tyrosine kinase-1 is placentally derived in normal pregnancy: first in vivo evidence |
| title_full | Circulating soluble fms-like tyrosine kinase-1 is placentally derived in normal pregnancy: first in vivo evidence |
| title_fullStr | Circulating soluble fms-like tyrosine kinase-1 is placentally derived in normal pregnancy: first in vivo evidence |
| title_full_unstemmed | Circulating soluble fms-like tyrosine kinase-1 is placentally derived in normal pregnancy: first in vivo evidence |
| title_short | Circulating soluble fms-like tyrosine kinase-1 is placentally derived in normal pregnancy: first in vivo evidence |
| title_sort | circulating soluble fms like tyrosine kinase 1 is placentally derived in normal pregnancy first in vivo evidence |
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