Gait in mild Alzheimer’s disease: feasibility of multi-centre measurement in the clinic and home with body-worn sensors: a pilot study
Gait is emerging as a potential diagnostic tool for cognitive decline. The ‘Deep and Frequent Phenotyping for Experimental Medicine in Dementia Study’ (D&FP;) is a multicenter feasibility study embedded in the United Kingdom Dementia Platform designed to determine participant acceptability a...
| Κύριοι συγγραφείς: | , , , , , , , , , , , , , , , , |
|---|---|
| Μορφή: | Journal article |
| Γλώσσα: | English |
| Έκδοση: |
IOS Press
2018
|
| _version_ | 1826271204569251840 |
|---|---|
| author | Mc Ardle, R Morris, R Hickey, A Del Din, S Koychev, I Gunn, RN Lawson, J Zamboni, G Ridha, B Sahakian, BJ Rowe, JB Thomas, A Zetterberg, H MacKay, C Lovestone, S Rochester, L Deep and Frequent Phenotyping study team |
| author_facet | Mc Ardle, R Morris, R Hickey, A Del Din, S Koychev, I Gunn, RN Lawson, J Zamboni, G Ridha, B Sahakian, BJ Rowe, JB Thomas, A Zetterberg, H MacKay, C Lovestone, S Rochester, L Deep and Frequent Phenotyping study team |
| author_sort | Mc Ardle, R |
| collection | OXFORD |
| description | Gait is emerging as a potential diagnostic tool for cognitive decline. The ‘Deep and Frequent Phenotyping for Experimental Medicine in Dementia Study’ (D&FP;) is a multicenter feasibility study embedded in the United Kingdom Dementia Platform designed to determine participant acceptability and feasibility of extensive and repeated phenotyping to determine the optimal combination of biomarkers to detect disease progression and identify early risk of Alzheimer’s disease (AD). Gait is included as a clinical biomarker. The tools to quantify gait in the clinic and home, and suitability for multi-center application have not been examined. Six centers from the National Institute for Health Research Translational Research Collaboration in Dementia initiative recruited 20 individuals with early onset AD. Participants wore a single wearable (tri-axial accelerometer) and completed both clinic-based and free-living gait assessment. A series of macro (behavioral) and micro (spatiotemporal) characteristics were derived from the resultant data using previously validated algorithms. Results indicate good participant acceptability, and potential for use of body-worn sensors in both the clinic and the home. Recommendations for future studies have been provided. Gait has been demonstrated to be a feasible and suitable measure, and future research should examine its suitability as a biomarker in AD. |
| first_indexed | 2024-03-06T21:52:59Z |
| format | Journal article |
| id | oxford-uuid:4bf41e6f-c598-4182-807f-17c81b2444ee |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:52:59Z |
| publishDate | 2018 |
| publisher | IOS Press |
| record_format | dspace |
| spelling | oxford-uuid:4bf41e6f-c598-4182-807f-17c81b2444ee2022-03-26T15:46:36ZGait in mild Alzheimer’s disease: feasibility of multi-centre measurement in the clinic and home with body-worn sensors: a pilot studyJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:4bf41e6f-c598-4182-807f-17c81b2444eeEnglishSymplectic Elements at OxfordIOS Press2018Mc Ardle, RMorris, RHickey, ADel Din, SKoychev, IGunn, RNLawson, JZamboni, GRidha, BSahakian, BJRowe, JBThomas, AZetterberg, HMacKay, CLovestone, SRochester, LDeep and Frequent Phenotyping study teamGait is emerging as a potential diagnostic tool for cognitive decline. The ‘Deep and Frequent Phenotyping for Experimental Medicine in Dementia Study’ (D&FP;) is a multicenter feasibility study embedded in the United Kingdom Dementia Platform designed to determine participant acceptability and feasibility of extensive and repeated phenotyping to determine the optimal combination of biomarkers to detect disease progression and identify early risk of Alzheimer’s disease (AD). Gait is included as a clinical biomarker. The tools to quantify gait in the clinic and home, and suitability for multi-center application have not been examined. Six centers from the National Institute for Health Research Translational Research Collaboration in Dementia initiative recruited 20 individuals with early onset AD. Participants wore a single wearable (tri-axial accelerometer) and completed both clinic-based and free-living gait assessment. A series of macro (behavioral) and micro (spatiotemporal) characteristics were derived from the resultant data using previously validated algorithms. Results indicate good participant acceptability, and potential for use of body-worn sensors in both the clinic and the home. Recommendations for future studies have been provided. Gait has been demonstrated to be a feasible and suitable measure, and future research should examine its suitability as a biomarker in AD. |
| spellingShingle | Mc Ardle, R Morris, R Hickey, A Del Din, S Koychev, I Gunn, RN Lawson, J Zamboni, G Ridha, B Sahakian, BJ Rowe, JB Thomas, A Zetterberg, H MacKay, C Lovestone, S Rochester, L Deep and Frequent Phenotyping study team Gait in mild Alzheimer’s disease: feasibility of multi-centre measurement in the clinic and home with body-worn sensors: a pilot study |
| title | Gait in mild Alzheimer’s disease: feasibility of multi-centre measurement in the clinic and home with body-worn sensors: a pilot study |
| title_full | Gait in mild Alzheimer’s disease: feasibility of multi-centre measurement in the clinic and home with body-worn sensors: a pilot study |
| title_fullStr | Gait in mild Alzheimer’s disease: feasibility of multi-centre measurement in the clinic and home with body-worn sensors: a pilot study |
| title_full_unstemmed | Gait in mild Alzheimer’s disease: feasibility of multi-centre measurement in the clinic and home with body-worn sensors: a pilot study |
| title_short | Gait in mild Alzheimer’s disease: feasibility of multi-centre measurement in the clinic and home with body-worn sensors: a pilot study |
| title_sort | gait in mild alzheimer s disease feasibility of multi centre measurement in the clinic and home with body worn sensors a pilot study |
| work_keys_str_mv | AT mcardler gaitinmildalzheimersdiseasefeasibilityofmulticentremeasurementintheclinicandhomewithbodywornsensorsapilotstudy AT morrisr gaitinmildalzheimersdiseasefeasibilityofmulticentremeasurementintheclinicandhomewithbodywornsensorsapilotstudy AT hickeya gaitinmildalzheimersdiseasefeasibilityofmulticentremeasurementintheclinicandhomewithbodywornsensorsapilotstudy AT deldins gaitinmildalzheimersdiseasefeasibilityofmulticentremeasurementintheclinicandhomewithbodywornsensorsapilotstudy AT koychevi gaitinmildalzheimersdiseasefeasibilityofmulticentremeasurementintheclinicandhomewithbodywornsensorsapilotstudy AT gunnrn gaitinmildalzheimersdiseasefeasibilityofmulticentremeasurementintheclinicandhomewithbodywornsensorsapilotstudy AT lawsonj gaitinmildalzheimersdiseasefeasibilityofmulticentremeasurementintheclinicandhomewithbodywornsensorsapilotstudy AT zambonig gaitinmildalzheimersdiseasefeasibilityofmulticentremeasurementintheclinicandhomewithbodywornsensorsapilotstudy AT ridhab gaitinmildalzheimersdiseasefeasibilityofmulticentremeasurementintheclinicandhomewithbodywornsensorsapilotstudy AT sahakianbj gaitinmildalzheimersdiseasefeasibilityofmulticentremeasurementintheclinicandhomewithbodywornsensorsapilotstudy AT rowejb gaitinmildalzheimersdiseasefeasibilityofmulticentremeasurementintheclinicandhomewithbodywornsensorsapilotstudy AT thomasa gaitinmildalzheimersdiseasefeasibilityofmulticentremeasurementintheclinicandhomewithbodywornsensorsapilotstudy AT zetterbergh gaitinmildalzheimersdiseasefeasibilityofmulticentremeasurementintheclinicandhomewithbodywornsensorsapilotstudy AT mackayc gaitinmildalzheimersdiseasefeasibilityofmulticentremeasurementintheclinicandhomewithbodywornsensorsapilotstudy AT lovestones gaitinmildalzheimersdiseasefeasibilityofmulticentremeasurementintheclinicandhomewithbodywornsensorsapilotstudy AT rochesterl gaitinmildalzheimersdiseasefeasibilityofmulticentremeasurementintheclinicandhomewithbodywornsensorsapilotstudy AT deepandfrequentphenotypingstudyteam gaitinmildalzheimersdiseasefeasibilityofmulticentremeasurementintheclinicandhomewithbodywornsensorsapilotstudy |