Mapping of the mouse homologue of the Wilson disease gene to mouse chromosome 8.
ATP7B, the gene altered in Wilson disease (WD) patients, lies in a block of homology shared between human chromosome 13q14 and the central region of mouse chromosome 14. However, we have mapped the murine homologue of ATP7B (Atp7b) to mouse chromosome 8 by somatic cell hybrid analysis. Analysis of 8...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
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1995
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| _version_ | 1826271205576933376 |
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| author | Reed, V Williamson, P Bull, P Cox, D Boyd, Y |
| author_facet | Reed, V Williamson, P Bull, P Cox, D Boyd, Y |
| author_sort | Reed, V |
| collection | OXFORD |
| description | ATP7B, the gene altered in Wilson disease (WD) patients, lies in a block of homology shared between human chromosome 13q14 and the central region of mouse chromosome 14. However, we have mapped the murine homologue of ATP7B (Atp7b) to mouse chromosome 8 by somatic cell hybrid analysis. Analysis of 80 interspecific backcross offspring was used to position Atp7b close to D8Mit3 and another ATPase locus, Atp4b, on mouse chromosome 8. ATP4B lies in 13q34 and is separated from ATP7B by several loci whose mouse homologues map to mouse chromosome 14. The assignment of Atp7b to mouse chromosome 8 identifies a previously unrecognized region of homology between this chromosome and human chromosome 13. This assignment suggests a possible location for the toxic milk mutation in the mouse, which has been proposed as a homologue of WD. |
| first_indexed | 2024-03-06T21:53:00Z |
| format | Journal article |
| id | oxford-uuid:4bf542b2-65d9-443a-b96f-e2fff17d510c |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:53:00Z |
| publishDate | 1995 |
| record_format | dspace |
| spelling | oxford-uuid:4bf542b2-65d9-443a-b96f-e2fff17d510c2022-03-26T15:46:37ZMapping of the mouse homologue of the Wilson disease gene to mouse chromosome 8.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:4bf542b2-65d9-443a-b96f-e2fff17d510cEnglishSymplectic Elements at Oxford1995Reed, VWilliamson, PBull, PCox, DBoyd, YATP7B, the gene altered in Wilson disease (WD) patients, lies in a block of homology shared between human chromosome 13q14 and the central region of mouse chromosome 14. However, we have mapped the murine homologue of ATP7B (Atp7b) to mouse chromosome 8 by somatic cell hybrid analysis. Analysis of 80 interspecific backcross offspring was used to position Atp7b close to D8Mit3 and another ATPase locus, Atp4b, on mouse chromosome 8. ATP4B lies in 13q34 and is separated from ATP7B by several loci whose mouse homologues map to mouse chromosome 14. The assignment of Atp7b to mouse chromosome 8 identifies a previously unrecognized region of homology between this chromosome and human chromosome 13. This assignment suggests a possible location for the toxic milk mutation in the mouse, which has been proposed as a homologue of WD. |
| spellingShingle | Reed, V Williamson, P Bull, P Cox, D Boyd, Y Mapping of the mouse homologue of the Wilson disease gene to mouse chromosome 8. |
| title | Mapping of the mouse homologue of the Wilson disease gene to mouse chromosome 8. |
| title_full | Mapping of the mouse homologue of the Wilson disease gene to mouse chromosome 8. |
| title_fullStr | Mapping of the mouse homologue of the Wilson disease gene to mouse chromosome 8. |
| title_full_unstemmed | Mapping of the mouse homologue of the Wilson disease gene to mouse chromosome 8. |
| title_short | Mapping of the mouse homologue of the Wilson disease gene to mouse chromosome 8. |
| title_sort | mapping of the mouse homologue of the wilson disease gene to mouse chromosome 8 |
| work_keys_str_mv | AT reedv mappingofthemousehomologueofthewilsondiseasegenetomousechromosome8 AT williamsonp mappingofthemousehomologueofthewilsondiseasegenetomousechromosome8 AT bullp mappingofthemousehomologueofthewilsondiseasegenetomousechromosome8 AT coxd mappingofthemousehomologueofthewilsondiseasegenetomousechromosome8 AT boydy mappingofthemousehomologueofthewilsondiseasegenetomousechromosome8 |