Tetramer-guided analysis of TCR beta-chain usage reveals a large repertoire of melan-A-specific CD8+ T cells in melanoma patients.

Tetramer-guided analysis of TCR beta-chain usage reveals a large repertoire of melan-A-specific CD8+ T cells in melanoma patients.

The assessment of the TCR repertoire expressed by tumor-specific CD8+ T lymphocytes has been hampered to date by the difficulty of targeting the analysis to lymphocytes directed against a single epitope. In the present study we have used fluorescent A2/Melan-A tetramers in conjunction with anti-CD8...

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Bibliographic Details
Main Authors:	Valmori, D, Dutoit, V, Liénard, D, Lejeune, F, Speiser, D, Rimoldi, D, Cerundolo, V, Dietrich, P, Cerottini, J, Romero, P
Format:	Journal article
Language:	English
Published:	2000

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