Mutagenesis studies on the iron binding ligands of clavaminic acid synthase.

Mutagenesis studies on conserved histidine residues identified as possible metal binding ligands in clavaminic acid synthase isozyme 2 were consistent with His-145 and His-280 acting as iron ligands, in support of crystallographic and previous mutagenesis studies. Mutagenesis of the four cysteines a...

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Príomhchruthaitheoirí:	Doan, L, Hassan, A, Lipscomb, S, Dhanda, A, Zhang, Z, Schofield, C
Formáid:	Journal article
Teanga:	English
Foilsithe / Cruthaithe:	2000

Cur síos
Achoimre:	Mutagenesis studies on conserved histidine residues identified as possible metal binding ligands in clavaminic acid synthase isozyme 2 were consistent with His-145 and His-280 acting as iron ligands, in support of crystallographic and previous mutagenesis studies. Mutagenesis of the four cysteines and a glutamine residue, conserved in both clavaminic acid synthase isozymes 1 and 2, demonstrated that none of these residues is essential for activity.

Mutagenesis studies on the iron binding ligands of clavaminic acid synthase.

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