1 α ,25-dihydroxyvitamin D3 acts via transforming growth factor- β to up-regulate expression of immunosuppressive CD73 on human CD4 + Foxp3 - T cells
Vitamin D deficiency is associated with increased incidence and severity of various immune‐mediated diseases. Active vitamin D (1α,25‐dihydroxyvitamin D3; 1,25(OH)2D3) up‐regulates CD4+ T‐cell expression of the purine ectonucleotidase CD39, a molecule that is associated with the generation of anti‐i...
Main Authors: | , , , , |
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Format: | Journal article |
Published: |
Wiley
2015
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