1 α ,25-dihydroxyvitamin D3 acts via transforming growth factor- β to up-regulate expression of immunosuppressive CD73 on human CD4 + Foxp3 - T cells

1 α ,25-dihydroxyvitamin D3 acts via transforming growth factor- β to up-regulate expression of immunosuppressive CD73 on human CD4 + Foxp3 - T cells

Vitamin D deficiency is associated with increased incidence and severity of various immune‐mediated diseases. Active vitamin D (1α,25‐dihydroxyvitamin D3; 1,25(OH)2D3) up‐regulates CD4+ T‐cell expression of the purine ectonucleotidase CD39, a molecule that is associated with the generation of anti‐i...

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Bibliographic Details
Main Authors:	Mann, E, Chambers, E, Chen, Y, Richards, D, Hawrylowicz, C
Format:	Journal article
Published:	Wiley 2015

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