Statistical and Computational Methodology for the Analysis of Forensic DNA Mixtures with Artefacts
<p>This thesis proposes and discusses a statistical model for interpreting forensic DNA mixtures. We develop methods for estimation of model parameters and assessing the uncertainty of the estimated quantities. Further, we discuss how to interpret the mixture in terms of predicting the set of...
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| Format: | Thesis |
| Language: | English |
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2014
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| _version_ | 1826316603912880128 |
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| author | Graversen, T |
| author2 | Lauritzen, S |
| author_facet | Lauritzen, S Graversen, T |
| author_sort | Graversen, T |
| collection | OXFORD |
| description | <p>This thesis proposes and discusses a statistical model for interpreting forensic DNA mixtures. We develop methods for estimation of model parameters and assessing the uncertainty of the estimated quantities. Further, we discuss how to interpret the mixture in terms of predicting the set of contributors.</p> <p>We emphasise the importance of challenging any interpretation of a particular mixture, and for this purpose we develop a set of diagnostic tools that can be used in assessing the adequacy of the model to the data at hand as well as in a systematic validation of the model on experimental data.</p> <p>An important feature of this work is that all methodology is developed entirely within the framework of the adopted model, ensuring a transparent and consistent analysis.</p> <p>To overcome the challenge that lies in handling the large state space for DNA profiles, we propose a representation of a genotype that exhibits a Markov structure. Further, we develop methods for efficient and exact computation in a Bayesian network. An implementation of the model and methodology is available through the R package DNAmixtures.</p> |
| first_indexed | 2024-03-06T21:53:54Z |
| format | Thesis |
| id | oxford-uuid:4c3bfc88-25e7-4c5b-968f-10a35f5b82b0 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-12-09T03:48:00Z |
| publishDate | 2014 |
| record_format | dspace |
| spelling | oxford-uuid:4c3bfc88-25e7-4c5b-968f-10a35f5b82b02024-12-08T10:52:53ZStatistical and Computational Methodology for the Analysis of Forensic DNA Mixtures with ArtefactsThesishttp://purl.org/coar/resource_type/c_db06uuid:4c3bfc88-25e7-4c5b-968f-10a35f5b82b0Mathematical genetics and bioinformatics (statistics)Statistics (see also social sciences)Computationally-intensive statisticsStatistics (social sciences)ComputingEnglishOxford University Research Archive - Valet2014Graversen, TLauritzen, S<p>This thesis proposes and discusses a statistical model for interpreting forensic DNA mixtures. We develop methods for estimation of model parameters and assessing the uncertainty of the estimated quantities. Further, we discuss how to interpret the mixture in terms of predicting the set of contributors.</p> <p>We emphasise the importance of challenging any interpretation of a particular mixture, and for this purpose we develop a set of diagnostic tools that can be used in assessing the adequacy of the model to the data at hand as well as in a systematic validation of the model on experimental data.</p> <p>An important feature of this work is that all methodology is developed entirely within the framework of the adopted model, ensuring a transparent and consistent analysis.</p> <p>To overcome the challenge that lies in handling the large state space for DNA profiles, we propose a representation of a genotype that exhibits a Markov structure. Further, we develop methods for efficient and exact computation in a Bayesian network. An implementation of the model and methodology is available through the R package DNAmixtures.</p> |
| spellingShingle | Mathematical genetics and bioinformatics (statistics) Statistics (see also social sciences) Computationally-intensive statistics Statistics (social sciences) Computing Graversen, T Statistical and Computational Methodology for the Analysis of Forensic DNA Mixtures with Artefacts |
| title | Statistical and Computational Methodology for the Analysis of Forensic DNA Mixtures with Artefacts |
| title_full | Statistical and Computational Methodology for the Analysis of Forensic DNA Mixtures with Artefacts |
| title_fullStr | Statistical and Computational Methodology for the Analysis of Forensic DNA Mixtures with Artefacts |
| title_full_unstemmed | Statistical and Computational Methodology for the Analysis of Forensic DNA Mixtures with Artefacts |
| title_short | Statistical and Computational Methodology for the Analysis of Forensic DNA Mixtures with Artefacts |
| title_sort | statistical and computational methodology for the analysis of forensic dna mixtures with artefacts |
| topic | Mathematical genetics and bioinformatics (statistics) Statistics (see also social sciences) Computationally-intensive statistics Statistics (social sciences) Computing |
| work_keys_str_mv | AT graversent statisticalandcomputationalmethodologyfortheanalysisofforensicdnamixtureswithartefacts |