Triggered intracellular activation of disulfide crosslinked polyelectrolyte gene delivery complexes with extended systemic circulation in vivo.
We have developed polyelectrolyte gene delivery vectors that display good extracellular stability and are activated intracellularly to permit transgene expression. The strategy comprises covalent crosslinking of primary amines in poly-L-lysine/DNA complexes with a crosslinking agent that can later b...
Main Authors: | Oupický, D, Carlisle, R, Seymour, L |
---|---|
Formato: | Journal article |
Idioma: | English |
Publicado em: |
Springer Nature
2001
|
Registos relacionados
-
Importance of lateral and steric stabilization of polyelectrolyte gene delivery vectors for extended systemic circulation
Por: Oupicky, D, et al.
Publicado em: (2002) -
Laterally stabilized complexes of DNA with linear reducible polycations: strategy for triggered intracellular activation of DNA delivery vectors
Por: Oupický, D, et al.
Publicado em: (2001) -
Polymer-coated polyethylenimine/DNA complexes designed for triggered activation by intracellular reduction.
Por: Carlisle, R, et al.
Publicado em: (2004) -
Polymer-coated polyplexes designed for triggered activation utilising intracellular reduction
Por: Briggs, S, et al.
Publicado em: (2004) -
Ultrasound-enhanced transfection activity of HPMA-stabilized DNA polyplexes with prolonged plasma circulation.
Por: Zhou, Q, et al.
Publicado em: (2005)