Robust Gag-specific T cell responses characterize viremia control in HIV-2 infection
HIV-2 infection in the majority of infected subjects follows an attenuated disease course that distinguishes it from infection with HIV-1. Antigen-specific T cells are pivotal in the management of chronic viral infections but are not sufficient to control viral replication in HIV-1-positive subjects...
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2007
|
| _version_ | 1826271276352667648 |
|---|---|
| author | Leligdowicz, A Yindom, L Onyango, C Sarge-Njie, R Alabi, A Cotten, M Vincent, T Da Costa, C Aaby, P Jaye, A Dong, T McMichael, A Whittle, H Rowland-Jones, S |
| author_facet | Leligdowicz, A Yindom, L Onyango, C Sarge-Njie, R Alabi, A Cotten, M Vincent, T Da Costa, C Aaby, P Jaye, A Dong, T McMichael, A Whittle, H Rowland-Jones, S |
| author_sort | Leligdowicz, A |
| collection | OXFORD |
| description | HIV-2 infection in the majority of infected subjects follows an attenuated disease course that distinguishes it from infection with HIV-1. Antigen-specific T cells are pivotal in the management of chronic viral infections but are not sufficient to control viral replication in HIV-1-positive subjects, and their function in HIV-2 infection is not fully established. In a community-based cohort of HIV-2 long-term nonprogressors in rural Guinea-Bissau, we performed what we believe is the first comprehensive analysis of HIV-2-specific immune responses. We demonstrate that Gag is the most immunogenic protein. The magnitude of the IFN-γ immune response to the HIV-2 proteome was inversely correlated with HIV-2 viremia, and this relationship was specifically due to the targeting of Gag. Furthermore, patients with undetectable viremia had greater Gag-specific responses compared with patients with high viral replication. The most frequently recognized peptides clustered within a defined region of Gag, and responses to a single peptide in this region were associated with low viral burden. The consistent relationship between Gag-specific immune responses and viremia control suggests that T cell responses are vital in determining the superior outcome of HIV-2 infection. A better understanding of how HIV-2 infection is controlled may identify correlates of effective protective immunity essential for the design of HIV vaccines. |
| first_indexed | 2024-03-06T21:54:08Z |
| format | Journal article |
| id | oxford-uuid:4c4f47f6-971e-4bd5-aa5d-d90eaa6df976 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:54:08Z |
| publishDate | 2007 |
| record_format | dspace |
| spelling | oxford-uuid:4c4f47f6-971e-4bd5-aa5d-d90eaa6df9762022-03-26T15:48:46ZRobust Gag-specific T cell responses characterize viremia control in HIV-2 infectionJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:4c4f47f6-971e-4bd5-aa5d-d90eaa6df976EnglishSymplectic Elements at Oxford2007Leligdowicz, AYindom, LOnyango, CSarge-Njie, RAlabi, ACotten, MVincent, TDa Costa, CAaby, PJaye, ADong, TMcMichael, AWhittle, HRowland-Jones, SHIV-2 infection in the majority of infected subjects follows an attenuated disease course that distinguishes it from infection with HIV-1. Antigen-specific T cells are pivotal in the management of chronic viral infections but are not sufficient to control viral replication in HIV-1-positive subjects, and their function in HIV-2 infection is not fully established. In a community-based cohort of HIV-2 long-term nonprogressors in rural Guinea-Bissau, we performed what we believe is the first comprehensive analysis of HIV-2-specific immune responses. We demonstrate that Gag is the most immunogenic protein. The magnitude of the IFN-γ immune response to the HIV-2 proteome was inversely correlated with HIV-2 viremia, and this relationship was specifically due to the targeting of Gag. Furthermore, patients with undetectable viremia had greater Gag-specific responses compared with patients with high viral replication. The most frequently recognized peptides clustered within a defined region of Gag, and responses to a single peptide in this region were associated with low viral burden. The consistent relationship between Gag-specific immune responses and viremia control suggests that T cell responses are vital in determining the superior outcome of HIV-2 infection. A better understanding of how HIV-2 infection is controlled may identify correlates of effective protective immunity essential for the design of HIV vaccines. |
| spellingShingle | Leligdowicz, A Yindom, L Onyango, C Sarge-Njie, R Alabi, A Cotten, M Vincent, T Da Costa, C Aaby, P Jaye, A Dong, T McMichael, A Whittle, H Rowland-Jones, S Robust Gag-specific T cell responses characterize viremia control in HIV-2 infection |
| title | Robust Gag-specific T cell responses characterize viremia control in HIV-2 infection |
| title_full | Robust Gag-specific T cell responses characterize viremia control in HIV-2 infection |
| title_fullStr | Robust Gag-specific T cell responses characterize viremia control in HIV-2 infection |
| title_full_unstemmed | Robust Gag-specific T cell responses characterize viremia control in HIV-2 infection |
| title_short | Robust Gag-specific T cell responses characterize viremia control in HIV-2 infection |
| title_sort | robust gag specific t cell responses characterize viremia control in hiv 2 infection |
| work_keys_str_mv | AT leligdowicza robustgagspecifictcellresponsescharacterizeviremiacontrolinhiv2infection AT yindoml robustgagspecifictcellresponsescharacterizeviremiacontrolinhiv2infection AT onyangoc robustgagspecifictcellresponsescharacterizeviremiacontrolinhiv2infection AT sargenjier robustgagspecifictcellresponsescharacterizeviremiacontrolinhiv2infection AT alabia robustgagspecifictcellresponsescharacterizeviremiacontrolinhiv2infection AT cottenm robustgagspecifictcellresponsescharacterizeviremiacontrolinhiv2infection AT vincentt robustgagspecifictcellresponsescharacterizeviremiacontrolinhiv2infection AT dacostac robustgagspecifictcellresponsescharacterizeviremiacontrolinhiv2infection AT aabyp robustgagspecifictcellresponsescharacterizeviremiacontrolinhiv2infection AT jayea robustgagspecifictcellresponsescharacterizeviremiacontrolinhiv2infection AT dongt robustgagspecifictcellresponsescharacterizeviremiacontrolinhiv2infection AT mcmichaela robustgagspecifictcellresponsescharacterizeviremiacontrolinhiv2infection AT whittleh robustgagspecifictcellresponsescharacterizeviremiacontrolinhiv2infection AT rowlandjoness robustgagspecifictcellresponsescharacterizeviremiacontrolinhiv2infection |