Long-term memory prepares neural activity for perception.
Past experience provides a rich source of predictive information about the world that could be used to guide and optimize ongoing perception. However, the neural mechanisms that integrate information coded in long-term memory (LTM) with ongoing perceptual processing remain unknown. Here, we explore...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2012
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| _version_ | 1797067311623962624 |
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| author | Stokes, M Atherton, K Patai, E Nobre, A |
| author_facet | Stokes, M Atherton, K Patai, E Nobre, A |
| author_sort | Stokes, M |
| collection | OXFORD |
| description | Past experience provides a rich source of predictive information about the world that could be used to guide and optimize ongoing perception. However, the neural mechanisms that integrate information coded in long-term memory (LTM) with ongoing perceptual processing remain unknown. Here, we explore how the contents of LTM optimize perception by modulating anticipatory brain states. By using a paradigm that integrates LTM and attentional orienting, we first demonstrate that the contents of LTM sharpen perceptual sensitivity for targets presented at memory-predicted spatial locations. Next, we examine oscillations in EEG to show that memory-guided attention is associated with spatially specific desynchronization of alpha-band activity over visual cortex. Additionally, we use functional MRI to confirm that target-predictive spatial information stored in LTM triggers spatiotopic modulation of preparatory activity in extrastriate visual cortex. Finally, functional MRI results also implicate an integrated cortical network, including the hippocampus and a dorsal frontoparietal circuit, as a likely candidate for organizing preparatory states in visual cortex according to the contents of LTM. |
| first_indexed | 2024-03-06T21:54:27Z |
| format | Journal article |
| id | oxford-uuid:4c6f74ee-05a3-4351-b0b6-900af1eceb47 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:54:27Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | oxford-uuid:4c6f74ee-05a3-4351-b0b6-900af1eceb472022-03-26T15:49:24ZLong-term memory prepares neural activity for perception.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:4c6f74ee-05a3-4351-b0b6-900af1eceb47EnglishSymplectic Elements at Oxford2012Stokes, MAtherton, KPatai, ENobre, APast experience provides a rich source of predictive information about the world that could be used to guide and optimize ongoing perception. However, the neural mechanisms that integrate information coded in long-term memory (LTM) with ongoing perceptual processing remain unknown. Here, we explore how the contents of LTM optimize perception by modulating anticipatory brain states. By using a paradigm that integrates LTM and attentional orienting, we first demonstrate that the contents of LTM sharpen perceptual sensitivity for targets presented at memory-predicted spatial locations. Next, we examine oscillations in EEG to show that memory-guided attention is associated with spatially specific desynchronization of alpha-band activity over visual cortex. Additionally, we use functional MRI to confirm that target-predictive spatial information stored in LTM triggers spatiotopic modulation of preparatory activity in extrastriate visual cortex. Finally, functional MRI results also implicate an integrated cortical network, including the hippocampus and a dorsal frontoparietal circuit, as a likely candidate for organizing preparatory states in visual cortex according to the contents of LTM. |
| spellingShingle | Stokes, M Atherton, K Patai, E Nobre, A Long-term memory prepares neural activity for perception. |
| title | Long-term memory prepares neural activity for perception. |
| title_full | Long-term memory prepares neural activity for perception. |
| title_fullStr | Long-term memory prepares neural activity for perception. |
| title_full_unstemmed | Long-term memory prepares neural activity for perception. |
| title_short | Long-term memory prepares neural activity for perception. |
| title_sort | long term memory prepares neural activity for perception |
| work_keys_str_mv | AT stokesm longtermmemorypreparesneuralactivityforperception AT athertonk longtermmemorypreparesneuralactivityforperception AT pataie longtermmemorypreparesneuralactivityforperception AT nobrea longtermmemorypreparesneuralactivityforperception |