Long-range regulation of alpha-globin gene expression.

Long-range regulation of alpha-globin gene expression.

Over the past 20 years, there has been an increasing awareness that gene expression can be regulated by multiple cis-acting sequences located at considerable distances (10-1000 kb) from the genes they control. Detailed investigation of a few specialized mammalian genes, including the genes controlli...

Bibliografiset tiedot
Päätekijät:	Higgs, D, Vernimmen, D, Wood, B
Aineistotyyppi:	Journal article
Kieli:	English
Julkaistu:	2008

Samankaltaisia teoksia

Chapter 5 Long-Range Regulation of α-Globin Gene Expression
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Long-range regulation of alpha globin gene expression during erythropoiesis.
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Long-range chromosomal interactions regulate the timing of the transition between poised and active gene expression.
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Long-range chromosomal interactions regulate the timing of the transition between poised and active gene expression
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Understanding alpha-globin gene regulation: Aiming to improve the management of thalassemia.
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Role of upstream DNase I hypersensitive sites in the regulation of human alpha globin gene expression.
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GEOGRAPHIC-DISTRIBUTION OF ALPHA-GLOBIN AND BETA-GLOBIN GENE-CLUSTER POLYMORPHISMS
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The role of histone deacetylases in repressing alpha-globin gene expression in non-erythroid cells.
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Analysis of the human alpha-globin gene cluster in transgenic mice.
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Tissue-specific histone modification and transcription factor binding in alpha globin gene expression.
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The mechanism of alpha-globin activation during erythropoiesis
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The mouse alpha-globin locus regulatory element.
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The role of the polycomb complex in silencing alpha-globin gene expression in nonerythroid cells.
Tekijä: Garrick, D, et al.
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Molecular rearrangements of the human alpha-globin gene cluster.
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Identification of a conserved erythroid specific domain of histone acetylation across the alpha-globin gene cluster.
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Interplay between DNA and histone methylation at an alpha-globin gene silenced by antisense RNA
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Cis-acting sequences regulating expression of the human alpha-globin cluster lie within constitutively open chromatin.
Tekijä: Vyas, P, et al.
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Conservation of position and sequence of a novel, widely expressed gene containing the major human alpha-globin regulatory element.
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Deletion of the alpha-globin gene cluster as a cause of acquired alpha-thalassemia in myelodysplastic syndrome.
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REGULATION OF EXPRESSION FROM THE HUMAN BETA-GLOBIN GENE DOMAIN
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The regulation of ζ-globin expression
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The structure of a human alpha-globin pseudogene and its relationship to alpha-globin gene duplication.
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Chromosome looping at the human alpha-globin locus is mediated via the major upstream regulatory element (HS -40).
Tekijä: Vernimmen, D, et al.
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Alpha-thalassemia caused by a large (62 kb) deletion upstream of the human alpha globin gene cluster.
Tekijä: Hatton, C, et al.
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Transcriptional promiscuity of the human alpha-globin gene.
Tekijä: Whitelaw, E, et al.
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Alpha globin genotypes in two North European populations.
Tekijä: Flint, J, et al.
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Independent recombination events between the duplicated human alpha globin genes; implications for their concerted evolution.
Tekijä: Higgs, D, et al.
Julkaistu: (1984)

Adventitious changes in long-range gene expression caused by polymorphic structural variation and promoter competition.
Tekijä: Lower, K, et al.
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Regulation of human embryonic globin genes zeta 2 and epsilon in stably transformed mouse erythroleukemia cells.
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Transcriptional activity of the human pseudogene psi alpha globin compared with alpha globin, its functional gene counterpart.
Tekijä: Whitelaw, E, et al.
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The transcriptional regulation of the zeta-globin gene
Tekijä: Liu, S
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Does Transcription of Remote alpha-Globin Regulatory Elements Affect Their Function?
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Expression of the human alpha-globin cluster in the absence of the major regulatory element Mcs-R2
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Differences in the patterns of transcription factor binding in the human and mouse alpha globin clusters point to potential differences in their regulation.
Tekijä: De Gobbi, M, et al.
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The organization of the tadpole and adult alpha globin genes of Xenopus laevis.
Tekijä: Patient, R, et al.
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COMPARISON OF THE ALPHA-GLOBIN GENE-CLUSTER STRUCTURE IN PERISSODACTYLA
Tekijä: Flint, J, et al.
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Characterization of a widely expressed gene (LUC7-LIKE; LUC7L) defining the centromeric boundary of the human alpha-globin domain.
Tekijä: Tufarelli, C, et al.
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Is there a role for CTCF binding sites in regulating the structure or function of the a globin gene cluster?
Tekijä: Anguita, E, et al.
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Identification of mutations in a trans-acting factor with different effects on alpha and beta globin expression.
Tekijä: Viprakasit, V, et al.
Julkaistu: (2000)