Variants in ST8SIA1 do not play a major role in susceptibility to multiple sclerosis in Canadian families.
Multiple sclerosis (MS) is a complex trait with a significant genetic component. Recent work has implicated the ST8SIA1 gene, encoding a ganglioside synthase, in susceptibility to the disease, perhaps with a parent-of-origin effect. In this investigation of 1318 MS patients from 756 Canadian familie...
| Main Authors: | , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2009
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| _version_ | 1797067326179246080 |
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| author | Ramagopalan, S Morrison, K Para, A Handel, A Disanto, G Handunnetthi, L Orton, S Sadovnick, A Ebers, G |
| author_facet | Ramagopalan, S Morrison, K Para, A Handel, A Disanto, G Handunnetthi, L Orton, S Sadovnick, A Ebers, G |
| author_sort | Ramagopalan, S |
| collection | OXFORD |
| description | Multiple sclerosis (MS) is a complex trait with a significant genetic component. Recent work has implicated the ST8SIA1 gene, encoding a ganglioside synthase, in susceptibility to the disease, perhaps with a parent-of-origin effect. In this investigation of 1318 MS patients from 756 Canadian families, we analysed the transmission of the four single nucleotide polymorphisms in ST8SIA previously shown to be associated with MS. No significant association was found in the entire sample or when stratifying by transmitting parent, indicating that this gene plays little or no role in susceptibility to MS in the Canadian population. |
| first_indexed | 2024-03-06T21:54:40Z |
| format | Journal article |
| id | oxford-uuid:4c7fee71-6e69-4047-8bd4-0130b212b308 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:54:40Z |
| publishDate | 2009 |
| record_format | dspace |
| spelling | oxford-uuid:4c7fee71-6e69-4047-8bd4-0130b212b3082022-03-26T15:49:50ZVariants in ST8SIA1 do not play a major role in susceptibility to multiple sclerosis in Canadian families.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:4c7fee71-6e69-4047-8bd4-0130b212b308EnglishSymplectic Elements at Oxford2009Ramagopalan, SMorrison, KPara, AHandel, ADisanto, GHandunnetthi, LOrton, SSadovnick, AEbers, GMultiple sclerosis (MS) is a complex trait with a significant genetic component. Recent work has implicated the ST8SIA1 gene, encoding a ganglioside synthase, in susceptibility to the disease, perhaps with a parent-of-origin effect. In this investigation of 1318 MS patients from 756 Canadian families, we analysed the transmission of the four single nucleotide polymorphisms in ST8SIA previously shown to be associated with MS. No significant association was found in the entire sample or when stratifying by transmitting parent, indicating that this gene plays little or no role in susceptibility to MS in the Canadian population. |
| spellingShingle | Ramagopalan, S Morrison, K Para, A Handel, A Disanto, G Handunnetthi, L Orton, S Sadovnick, A Ebers, G Variants in ST8SIA1 do not play a major role in susceptibility to multiple sclerosis in Canadian families. |
| title | Variants in ST8SIA1 do not play a major role in susceptibility to multiple sclerosis in Canadian families. |
| title_full | Variants in ST8SIA1 do not play a major role in susceptibility to multiple sclerosis in Canadian families. |
| title_fullStr | Variants in ST8SIA1 do not play a major role in susceptibility to multiple sclerosis in Canadian families. |
| title_full_unstemmed | Variants in ST8SIA1 do not play a major role in susceptibility to multiple sclerosis in Canadian families. |
| title_short | Variants in ST8SIA1 do not play a major role in susceptibility to multiple sclerosis in Canadian families. |
| title_sort | variants in st8sia1 do not play a major role in susceptibility to multiple sclerosis in canadian families |
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