The epidermis as an adjuvant
It is now clear that the epidermis has an active role in local immune responses in the skin. Keratinocytes are involved early in inflammation by providing first-line innate mechanisms and, in addition, can contribute to adaptive immune responses that may be associated with clinical disease. Moreover...
| Main Authors: | , |
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| Formato: | Journal article |
| Idioma: | English |
| Publicado: |
2012
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| _version_ | 1826271319494230016 |
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| author | Gutowska-Owsiak, D Ogg, G |
| author_facet | Gutowska-Owsiak, D Ogg, G |
| author_sort | Gutowska-Owsiak, D |
| collection | OXFORD |
| description | It is now clear that the epidermis has an active role in local immune responses in the skin. Keratinocytes are involved early in inflammation by providing first-line innate mechanisms and, in addition, can contribute to adaptive immune responses that may be associated with clinical disease. Moreover, keratinocytes are capable of enhancing and shaping the outcome of inflammation in response to stimuli and promoting particular types of immune bias. Through understanding the underlying mechanisms, the role of keratinocytes in disease pathogenesis will be further defined, which is likely to lead to the identification of potential targets for prophylactic or therapeutic intervention. © 2012 The Society for Investigative Dermatology. |
| first_indexed | 2024-03-06T21:54:48Z |
| format | Journal article |
| id | oxford-uuid:4c8af56c-1ebf-4b5e-9b29-5e100db3713a |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:54:48Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | oxford-uuid:4c8af56c-1ebf-4b5e-9b29-5e100db3713a2022-03-26T15:50:00ZThe epidermis as an adjuvantJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:4c8af56c-1ebf-4b5e-9b29-5e100db3713aEnglishSymplectic Elements at Oxford2012Gutowska-Owsiak, DOgg, GIt is now clear that the epidermis has an active role in local immune responses in the skin. Keratinocytes are involved early in inflammation by providing first-line innate mechanisms and, in addition, can contribute to adaptive immune responses that may be associated with clinical disease. Moreover, keratinocytes are capable of enhancing and shaping the outcome of inflammation in response to stimuli and promoting particular types of immune bias. Through understanding the underlying mechanisms, the role of keratinocytes in disease pathogenesis will be further defined, which is likely to lead to the identification of potential targets for prophylactic or therapeutic intervention. © 2012 The Society for Investigative Dermatology. |
| spellingShingle | Gutowska-Owsiak, D Ogg, G The epidermis as an adjuvant |
| title | The epidermis as an adjuvant |
| title_full | The epidermis as an adjuvant |
| title_fullStr | The epidermis as an adjuvant |
| title_full_unstemmed | The epidermis as an adjuvant |
| title_short | The epidermis as an adjuvant |
| title_sort | epidermis as an adjuvant |
| work_keys_str_mv | AT gutowskaowsiakd theepidermisasanadjuvant AT oggg theepidermisasanadjuvant AT gutowskaowsiakd epidermisasanadjuvant AT oggg epidermisasanadjuvant |