B cell–intrinsic TBK1 is essential for germinal center formation during infection and vaccination in mice

B cell–intrinsic TBK1 is essential for germinal center formation during infection and vaccination in mice

The germinal center (GC) is a site where somatic hypermutation and clonal selection are coupled for antibody affinity maturation against infections. However, how GCs are formed and regulated is incompletely understood. Here, we identified an unexpected role of Tank-binding kinase-1 (TBK1) as a cruci...

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Bibliographic Details
Main Authors: Lee, MSJ, Inoue, T, Ise, W, Matsuo-Dapaah, J, Wing, JB, Temizoz, B, Kobiyama, K, Hayashi, T, Patil, A, Sakaguchi, S, Simon, AK, Bezbradica, JS, Nagatoishi, S, Tsumoto, K, Inoue, J-I, Akira, S, Kurosaki, T, Ishii, KJ, Coban, C
Format: Journal article
Language:English
Published: Rockefeller University Press 2021

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