Fast and efficient DNA crosslinking and multiple orthogonal labelling by copper-free click chemistry.

Fast and efficient DNA crosslinking and multiple orthogonal labelling by copper-free click chemistry.

Two new dibenzocyclooctyne-thymidine monomers were incorporated into oligonucleotides and crosslinked to azide-labelled complementary strands across the DNA grooves. Equivalent reactions were successful using a (bicyclo[6.1.0]nonyne) alkyne. Oligonucleotides containing internal cyclooctyne and amino...

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Bibliografische gegevens
Hoofdauteurs:	Shelbourne, M, Brown, T, El-Sagheer, A
Formaat:	Journal article
Taal:	English
Gepubliceerd in:	2012

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