Fast and efficient DNA crosslinking and multiple orthogonal labelling by copper-free click chemistry.
Two new dibenzocyclooctyne-thymidine monomers were incorporated into oligonucleotides and crosslinked to azide-labelled complementary strands across the DNA grooves. Equivalent reactions were successful using a (bicyclo[6.1.0]nonyne) alkyne. Oligonucleotides containing internal cyclooctyne and amino...
Main Authors: | Shelbourne, M, Brown, T, El-Sagheer, A |
---|---|
Format: | Journal article |
Sprog: | English |
Udgivet: |
2012
|
Lignende værker
-
Fast copper-free click DNA ligation by the ring-strain promoted alkyne-azide cycloaddition reaction.
af: Shelbourne, M, et al.
Udgivet: (2011) -
Click chemistry with DNA.
af: El-Sagheer, A, et al.
Udgivet: (2010) -
A new modular approach to nanoassembly: stable and addressable DNA nanoconstructs via orthogonal click chemistries.
af: Gerrard, SR, et al.
Udgivet: (2012) -
Click chemistry - A versatile method for nucleic acid labelling, cyclisation and ligation
af: El-Sagheer, A, et al.
Udgivet: (2012) -
Rapid and efficient DNA strand cross-linking by click chemistry.
af: Kocalka, P, et al.
Udgivet: (2008)