The kinetic-segregation model: TCR triggering and beyond.
How the T cell receptor engages antigen is known, but not how that 'triggers' intracellular signaling. The first direct support for a mechanism based on the spatial reorganization of signaling proteins, proposed 10 years ago and referred to as the 'kinetic-segregation' model, is...
| Glavni autori: | , |
|---|---|
| Format: | Journal article |
| Jezik: | English |
| Izdano: |
2006
|
| _version_ | 1826271357228285952 |
|---|---|
| author | Davis, S Van Der Merwe, P |
| author_facet | Davis, S Van Der Merwe, P |
| author_sort | Davis, S |
| collection | OXFORD |
| description | How the T cell receptor engages antigen is known, but not how that 'triggers' intracellular signaling. The first direct support for a mechanism based on the spatial reorganization of signaling proteins, proposed 10 years ago and referred to as the 'kinetic-segregation' model, is now beginning to emerge, along with indications that it may also apply to the triggering of nonclonotypic receptors. We describe here the development of the model, review new data and suggest how the model fits a broader conceptual framework for receptor triggering. We also consider the capacity of the model, versus that of other proposals, to account for the established features of TCR triggering. |
| first_indexed | 2024-03-06T21:55:24Z |
| format | Journal article |
| id | oxford-uuid:4cc063e1-c5db-4c49-ad2a-69c64d602e18 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:55:24Z |
| publishDate | 2006 |
| record_format | dspace |
| spelling | oxford-uuid:4cc063e1-c5db-4c49-ad2a-69c64d602e182022-03-26T15:51:20ZThe kinetic-segregation model: TCR triggering and beyond.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:4cc063e1-c5db-4c49-ad2a-69c64d602e18EnglishSymplectic Elements at Oxford2006Davis, SVan Der Merwe, PHow the T cell receptor engages antigen is known, but not how that 'triggers' intracellular signaling. The first direct support for a mechanism based on the spatial reorganization of signaling proteins, proposed 10 years ago and referred to as the 'kinetic-segregation' model, is now beginning to emerge, along with indications that it may also apply to the triggering of nonclonotypic receptors. We describe here the development of the model, review new data and suggest how the model fits a broader conceptual framework for receptor triggering. We also consider the capacity of the model, versus that of other proposals, to account for the established features of TCR triggering. |
| spellingShingle | Davis, S Van Der Merwe, P The kinetic-segregation model: TCR triggering and beyond. |
| title | The kinetic-segregation model: TCR triggering and beyond. |
| title_full | The kinetic-segregation model: TCR triggering and beyond. |
| title_fullStr | The kinetic-segregation model: TCR triggering and beyond. |
| title_full_unstemmed | The kinetic-segregation model: TCR triggering and beyond. |
| title_short | The kinetic-segregation model: TCR triggering and beyond. |
| title_sort | kinetic segregation model tcr triggering and beyond |
| work_keys_str_mv | AT daviss thekineticsegregationmodeltcrtriggeringandbeyond AT vandermerwep thekineticsegregationmodeltcrtriggeringandbeyond AT daviss kineticsegregationmodeltcrtriggeringandbeyond AT vandermerwep kineticsegregationmodeltcrtriggeringandbeyond |